Department of Nephrology, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands.
Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.
Eur J Nutr. 2022 Mar;61(2):653-664. doi: 10.1007/s00394-021-02667-0. Epub 2021 Sep 7.
Circulating and dietary magnesium have been shown to be inversely associated with the prevalence of cardiovascular disease (CVD) and mortality in both high and low-risk populations. We aimed to examine the association between dietary magnesium intake and several measures of vascular structure and function in a prospective cohort.
We included 789 participants who participated in the vascular screening sub-cohort of the Hoorn Study, a population-based, prospective cohort study. Baseline dietary magnesium intake was estimated with a validated food frequency questionnaire and categorised in energy-adjusted magnesium intake tertiles. Several measurements of vascular structure and function were performed at baseline and most measurements were repeated after 8 years of follow-up (n = 432). Multivariable linear and logistic regression was performed to study the cross-sectional and longitudinal associations of magnesium intake and intima-media thickness (IMT), augmentation index (Aix), pulse wave velocity (PWV), flow-mediated dilatation (FMD), and peripheral arterial disease (PAD).
Mean absolute magnesium intake was 328 ± 83 mg/day and prior CVD and DM2 was present in 55 and 41% of the participants, respectively. Multivariable regression analyses did not demonstrate associations between magnesium intake and any of the vascular outcomes. Participants in the highest compared to the lowest magnesium intake tertile demonstrated in fully adjusted cross-sectional analyses a PWV of -0.21 m/s (95% confidence interval -1.95, 1.52), a FMD of -0.03% (-0.89, 0.83) and in longitudinal analyses an IMT of 0.01 mm (-0.03, 0.06), an Aix of 0.70% (-1.69, 3.07) and an odds ratio of 0.84 (0.23, 3.11) for PAD CONCLUSION: We did not find associations between dietary magnesium intake and multiple markers of vascular structure and function, in either cross-sectional or longitudinal analyses.
循环和饮食中的镁与心血管疾病（CVD）的患病率和高、低危人群的死亡率呈负相关。我们旨在研究饮食镁摄入量与前瞻性队列中血管结构和功能的几个指标之间的关系。
我们纳入了参加 Hoorn 研究血管筛查亚队列的 789 名参与者，该研究是一项基于人群的前瞻性队列研究。使用经过验证的食物频率问卷估计基线饮食镁摄入量，并按能量调整的镁摄入量三分位数进行分类。在基线时进行了几种血管结构和功能的测量，大多数测量在 8 年的随访后重复（n=432）。进行多变量线性和逻辑回归分析，以研究镁摄入量与内中膜厚度（IMT）、增强指数（Aix）、脉搏波速度（PWV）、血流介导的扩张（FMD）和外周动脉疾病（PAD）的横断面和纵向关联。
平均绝对镁摄入量为 328±83mg/天，分别有 55%和 41%的参与者存在既往 CVD 和 DM2。多变量回归分析未显示镁摄入量与任何血管结果之间存在关联。与最低镁摄入量三分位组相比，最高镁摄入量三分位组的参与者在完全调整的横断面分析中 PWV 降低了 0.21m/s（95%置信区间-1.95，1.52），FMD 降低了 0.03%（-0.89，0.83），在纵向分析中 IMT 增加了 0.01mm（-0.03，0.06），Aix 增加了 0.70%（-1.69，3.07），PAD 的优势比为 0.84（0.23，3.11）。
我们在横断面或纵向分析中均未发现饮食镁摄入量与多种血管结构和功能标志物之间存在关联。
