Department of Dermatology, Peking University First Hospital, Beijing, China.
Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China.
Dermatol Ther. 2019 Jul;32(4):e12832. doi: 10.1111/dth.12832. Epub 2019 Feb 21.
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are spectrum of rare, acute, and life-threatening delayed-type drug hypersensitivity reactions that are associated with high mortality rates. However, no therapeutic standard has been proposed for SJS/TEN. Here, we report a case of a patient diagnosed with Stevens-Johnson syndrome whose disease progression was halted by a single dose of etanercept and was treated successfully. In addition, we reviewed the literature reporting patients with SJS/TEN treated with similar regimens.
史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）是一种罕见的、急性的、危及生命的迟发性药物超敏反应谱，死亡率高。然而，目前尚未提出 SJS/TEN 的治疗标准。在这里，我们报告了一例诊断为史蒂文斯-约翰逊综合征的患者，其疾病进展被单次剂量依那西普阻止，并成功治疗。此外，我们还回顾了报告 SJS/TEN 患者用类似方案治疗的文献。
