Department of Dermatology & STD, ESI-PGIMSR Hospital, Basaidarapur, New Delhi, India.
Department of Dermatology & STD, NDMC Medical College & Hindu Rao Hospital, New Delhi, India.
Dermatol Ther. 2019 Mar;32(2):e12831. doi: 10.1111/dth.12831. Epub 2019 Feb 18.
Two patients, one with nail lichen striatus and second with idiopathic trachyonychia were treated with intramatriceal injections of platelet-rich plasma. A total of 0.1 ml of the plasma solution was injected into the matrix of the involved nails at three weekly intervals. Follow-up was done at each sitting and thereafter at 16 and 20 weeks. Assessment was done both photographically and by dermoscopy. Case 1 showed marked improvement within 3 weeks and Case 2 showed improvement within 6 weeks. No relapses were seen at 16 and 20 weeks of follow up. Intramatricial PRP is a safe and effective therapeutic modality in nail lichen striatus and idiopathic trachyonychia refractory to other treatment options. Further studies with larger sample size and controls are required to validate the results.
两名患者，一名患有甲营养不良性线状苔藓，另一名患有特发性甲粗厚，均接受了富血小板血浆的基质内注射治疗。总共将 0.1 毫升的血浆溶液在每三周的间隔时间内注入受累指甲的基质中。每次就诊时以及之后的 16 周和 20 周时进行随访。通过照相和皮肤镜进行评估。第 1 例在 3 周内明显改善，第 2 例在 6 周内改善。在 16 周和 20 周的随访中均未见复发。基质内 PRP 是治疗对其他治疗方法有抵抗的甲营养不良性线状苔藓和特发性甲粗厚的安全有效的治疗方法。需要进一步进行更大样本量和对照的研究来验证结果。
