Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milano, Italy.
Institute of Pathology, Luigi Sacco Hospital, Milano, Italy.
Travel Med Infect Dis. 2019 Sep-Oct;31:101378. doi: 10.1016/j.tmaid.2019.01.013. Epub 2019 Jan 17.
Gastrointestinal basidiobolomycosis (GIB) is a rare mycosis affecting almost exclusively immunocompetent subjects.
We describe a case of GIB caused by Basidiobolus ranarum in a 25-year-old Italian immunocompetent man resident in Ireland who presented a 2-month history of epigastric pain. Suspecting colon cancer he underwent a right hemicolectomy subsequently leading to a diagnosis of GIB by means of molecular biology. After surgery a 9-month therapy with itraconazole was employed with a good outcome. A review of medical literature regarding GIB cases published in the period 1964-2017 is presented.
One-hundred and two cases of GIB were included in this analysis. The disease was observed predominantly in male gender (74.5%) and children (41.2%). Abdominal pain was the single most common complaint (86.3%) followed by fever (40.2%) and evidence of an abdominal mass (30.4%). Peripheral blood eosinophilia was detected in 85.7% of cases. Most of the patients were diagnosed in Saudi Arabia (37.2%) followed by USA (21.6%) and Iran (20.6%). Surgery plus antifungal therapy was employed in the majority of patients (77.5%). An unfavourable outcome was documented globally in 18.6% of patients.
GIB seems to be an emerging intestinal mycosis among immunocompetent patients living in the Middle East and Arizona.
胃肠道芽生菌病（GIB）是一种罕见的真菌感染，几乎仅影响免疫功能正常的宿主。
我们描述了一例由 Basidiobolus ranarum 引起的胃肠道芽生菌病，患者为 25 岁的意大利免疫功能正常男性，居住在爱尔兰，有 2 个月的上腹痛病史。由于怀疑结肠癌，他接受了右半结肠切除术，随后通过分子生物学方法诊断为胃肠道芽生菌病。手术后，患者接受了为期 9 个月的伊曲康唑治疗，结果良好。回顾了 1964 年至 2017 年间发表的胃肠道芽生菌病病例的医学文献。
本分析共纳入 102 例胃肠道芽生菌病病例。该疾病主要发生于男性（74.5%）和儿童（41.2%）。腹痛是最常见的单一症状（86.3%），其次是发热（40.2%）和腹部肿块证据（30.4%）。85.7%的病例外周血嗜酸性粒细胞增多。大多数患者在沙特阿拉伯（37.2%）、美国（21.6%）和伊朗（20.6%）被诊断出该疾病。大多数患者接受了手术加抗真菌治疗（77.5%）。全球有 18.6%的患者预后不良。
胃肠道芽生菌病似乎是一种在中东和亚利桑那州居住的免疫功能正常患者中出现的新兴肠道真菌感染。
