Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, China; School of Materials Science & Engineering, Shandong University, Jinan 250100, China.
Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, China; School of Materials Science & Engineering, Shandong University, Jinan 250100, China.
Int J Biol Macromol. 2019 May 1;128:406-413. doi: 10.1016/j.ijbiomac.2019.01.077. Epub 2019 Jan 17.
Durable and biocompatible magnetic scaffolds prepared by simple approaches are important for the development of tissue engineering. In this work, by freeze-drying method and without using any crosslinker, we successfully fabricated FeO/chitosan magnetic scaffolds that belong to hard magnetic materials and are stable in physiological fluid. In vitro biocompatibility assay showed that mouse mesenchymal progenitor cells grow normally on the surface of the scaffolds. So these magnetic scaffolds have potentials to be used in tissue engineering as implants that independently direct drug targeting.
通过简单的方法制备出耐用且生物相容的磁性支架对于组织工程的发展非常重要。在这项工作中，我们通过冷冻干燥法，在不使用任何交联剂的情况下，成功制备了属于硬磁材料且在生理流体中稳定的 FeO/壳聚糖磁性支架。体外生物相容性试验表明，鼠间充质祖细胞在支架表面正常生长。因此，这些磁性支架有可能作为独立导向药物靶向的植入物用于组织工程。
