Bettini Simona, Bonfrate Valentina, Valli Ludovico, Giancane Gabriele
Department of Innovation Engineering, University Campus Ecotekne, University of Salento, Via per Monteroni, I-73100 Lecce, Italy.
National Interuniversity Consortium of Materials Science and Technology, INSTM, Via G. Giusti, 9, I-50121 Firenze, Italy.
Bioengineering (Basel). 2020 Nov 28;7(4):153. doi: 10.3390/bioengineering7040153.
The burst of research papers focused on the tissue engineering and regeneration recorded in the last years is justified by the increased skills in the synthesis of nanostructures able to confer peculiar biological and mechanical features to the matrix where they are dispersed. Inorganic, organic and hybrid nanostructures are proposed in the literature depending on the characteristic that has to be tuned and on the effect that has to be induced. In the field of the inorganic nanoparticles used for decorating the bio-scaffolds, the most recent contributions about the paramagnetic and superparamagnetic nanoparticles use was evaluated in the present contribution. The intrinsic properties of the paramagnetic nanoparticles, the possibility to be triggered by the simple application of an external magnetic field, their biocompatibility and the easiness of the synthetic procedures for obtaining them proposed these nanostructures as ideal candidates for positively enhancing the tissue regeneration. Herein, we divided the discussion into two macro-topics: the use of magnetic nanoparticles in scaffolds used for hard tissue engineering for soft tissue regeneration.
近年来，关于组织工程与再生的研究论文大量涌现，这是因为在纳米结构合成方面的技术有所提高，这些纳米结构能够赋予它们所分散的基质特殊的生物学和机械特性。根据需要调节的特性和要诱导产生的效果，文献中提出了无机、有机和混合纳米结构。在用于修饰生物支架的无机纳米颗粒领域，本论文评估了关于顺磁性和超顺磁性纳米颗粒应用的最新研究成果。顺磁性纳米颗粒的固有特性、通过简单施加外部磁场就能被触发的可能性、它们的生物相容性以及获得它们的合成方法的简便性，使得这些纳米结构成为积极促进组织再生的理想候选者。在此，我们将讨论分为两个大主题：磁性纳米颗粒在用于硬组织工程的支架中用于软组织再生的应用。
