Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
Int J Biol Macromol. 2019 Apr 15;127:450-459. doi: 10.1016/j.ijbiomac.2019.01.075. Epub 2019 Jan 17.
Keeping in view the importance of natural polysaccharide exudate gum in developing drug formulations. Herein this work, for making sterile drug carrier, the chemical modification of the gum polysaccharides has been carried out by graft copolymerization reaction by high energy radiation in the presence of biocompatible hydrophilic monomer N-vinyl imidazole and graphene oxide (GO). Cryo-SEM showed the porous nature of the polymer matrix. The crosslinking density of the material was influenced by both, GO content and radiation dose used during polymerization reaction. Non-Fickian diffusion mechanism was observed for the release of an anticancer drug gemcitabine from the polymer matrix. Due to mucoadhesive and antioxidant nature of the polymer, it could be applied as material for gastrointestinal drug delivery system.
鉴于天然多糖渗出胶在开发药物制剂方面的重要性。在这项工作中，为了制备无菌药物载体，通过高能辐射在生物相容性亲水性单体 N-乙烯基咪唑和氧化石墨烯 (GO) 的存在下，对胶多糖进行了接枝共聚反应的化学修饰。冷冻扫描电镜显示了聚合物基质的多孔性质。材料的交联密度受聚合反应过程中使用的 GO 含量和辐射剂量的影响。从聚合物基质中释放抗癌药物吉西他滨时观察到非菲克扩散机制。由于聚合物具有粘膜粘附和抗氧化的性质，它可以用作胃肠道药物传递系统的材料。
