Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
Int J Biol Macromol. 2020 Sep 15;159:264-275. doi: 10.1016/j.ijbiomac.2020.05.091. Epub 2020 May 15.
In this work, graft-copolymerization of poly vinylpyrollidone onto Azadirachta indica gum polysaccharide in the presence of crosslinker has been carried out to prepare the hydrogel for use in drug delivery. The polymers were characterized by cryo-SEM, AFM, FTIR, and C NMR. The gel strength, cross-link density, mesh size, thrombogenicity, antioxidant and mucoadhesion properties of the gum-PVP hydrogels were determined along with the evaluation of drug release profile of methyl prednisolone, a colonic anti-inflammatory agent, from the drug loaded hydrogels. Cryo SEM images showed the porous crosslinked structure of the polymer network. The drug release from the polymer followed non-Fickian diffusion mechanism. The polymers showed 71.47 ± 4.63% haemo-compatibility and 05.52 ± 0.59 Nmm gel strength. The value of DPPH radical scavenging assay (73.16 ± 04.85%) indicated that the gum-PVP polymers are antioxidant. The results of biocompatibility, antioxidant activity, mucoadhesion and drug release properties of the polymers inferred the use of this drug carrier for colonic drug delivery.
在本工作中，通过在交联剂存在下将聚乙烯吡咯烷酮接枝到印楝树胶多糖上，制备用于药物输送的水凝胶。通过冷冻 SEM、AFM、FTIR 和 C NMR 对聚合物进行了表征。测定了胶-PVP 水凝胶的凝胶强度、交联密度、网格尺寸、血栓形成性、抗氧化和粘膜粘附特性，并评价了载药水凝胶中作为结肠抗炎剂的甲基强的松龙的药物释放特性。冷冻 SEM 图像显示了聚合物网络的多孔交联结构。药物从聚合物中的释放遵循非菲克扩散机制。聚合物的血液相容性为 71.47 ± 4.63%，凝胶强度为 05.52 ± 0.59 Nmm。DPPH 自由基清除试验（73.16 ± 04.85%）的结果表明，胶-PVP 聚合物具有抗氧化活性。聚合物的生物相容性、抗氧化活性、粘膜粘附和药物释放特性的结果推断出该药物载体可用于结肠药物输送。
