Department of Immunology and Nano-Medicine, Institute of NeuroImmune Pharmacology, Centre for Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
Department of Pharmacology and Experimental Neuroscience, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
Drug Discov Today. 2019 Mar;24(3):873-882. doi: 10.1016/j.drudis.2019.01.006. Epub 2019 Jan 17.
Advanced central nervous system (CNS) therapies exhibited high efficacy but complete treatment of CNS diseases remains challenging owing to limited delivery of therapeutic agents to the brain. Multifunctional magnetic nanoparticles are investigated not only for site-specific drug delivery but also for theranostic applications aiming for an effective CNS therapy. Recently, surface engineering of magnetic nanoparticles was recognized as a crucial area of research to achieve precise therapy and imaging at molecular and cellular levels. This review reports state-of-the-art advancement in the development of surface-engineered magnetic nanoparticles targeting CNS diagnostics and therapies. The challenges and future prospects of magnetic theranostics are also discussed by considering the translation from bench to bedside. Successful translation of magnetic theranostics to the clinical setting will enable precise and efficient diagnostics and therapy to manage CNS diseases.
先进的中枢神经系统 (CNS) 疗法显示出了很高的疗效，但由于治疗药物向大脑的输送有限，完全治愈 CNS 疾病仍然具有挑战性。多功能磁性纳米粒子不仅被用于靶向药物输送，还被用于治疗诊断应用，旨在实现有效的 CNS 治疗。最近，磁性纳米粒子的表面工程被认为是实现分子和细胞水平精确治疗和成像的关键研究领域。本综述报告了针对 CNS 诊断和治疗的表面工程磁性纳米粒子的最新进展。通过考虑从实验室到临床的转化，还讨论了磁性治疗学的挑战和未来前景。将磁性治疗学成功转化到临床环境中，将能够实现精确和有效的诊断和治疗来管理 CNS 疾病。
