Department of Pharmacological Sciences, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China; Department of Biochemistry and Molecular Biology, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin, China.
Anhui Medical University, Hefei, China.
Pharmacol Res. 2019 Mar;141:409-417. doi: 10.1016/j.phrs.2019.01.024. Epub 2019 Jan 17.
NaoXinTong Capsule (NXT), a prescribed traditional Chinese medicine, is made up of 16 natural herbal materials with more than 200 identified bioactive compounds. Multiple protective effects of NXT on cardiovascular diseases including atherosclerosis, coronary artery disease, acute coronary syndrome, coronary microembolization, myocardial infarction, ischemic stroke and ischemia-reperfusion injury, have been reported by both clinical and basic studies. Biologically, these cardioprotective effects can be correlated to the actions of NXT on inflammation, apoptosis, oxidative stress, neovascularization, insulin sensitivity and lipid/glucose metabolism. NXT alone or in combination with the conventional interventions has been demonstrated potent therapeutic effects on cardiovascular diseases without causing significant adverse events, like the major bleeding. Compared with the conventional drugs, patients have a good tolerance and little resistance to NXT treatment. With the data and evidence reported from lab benches to clinical beds, we will update the cardioprotective properties of NXT and the involved mechanisms in this review. We hope the information provided in this review can help readers to better understand the insights for the long practice of this traditional Chinese medicine, and offer fresh perspectives.
脑心通胶囊（NXT）是一种传统的中药方剂，由 16 种天然草药组成，其中包含 200 多种已鉴定的生物活性化合物。临床和基础研究均表明，NXT 对心血管疾病（包括动脉粥样硬化、冠心病、急性冠脉综合征、冠状动脉微栓塞、心肌梗死、缺血性卒中和缺血再灌注损伤）具有多种保护作用。从生物学角度来看，这些心脏保护作用与 NXT 对炎症、细胞凋亡、氧化应激、血管生成、胰岛素敏感性和脂/糖代谢的作用有关。NXT 单独或与常规干预联合使用，已被证明对心血管疾病具有强大的治疗作用，且不会引起重大不良事件，如大出血。与传统药物相比，患者对 NXT 治疗具有良好的耐受性和较低的耐药性。根据从实验室到临床的研究数据和证据，我们将在本综述中更新 NXT 的心脏保护特性及其相关机制。我们希望本综述提供的信息能帮助读者更好地理解这种传统中药长期应用的独到之处，并提供新的视角。
