Zhang Wei-Jian, Chen Rui-Qi, Tang Xuan, Li Pei-Bo, Wang Jian, Wu Hai-Ke, Xu Ning, Zou Ming-Fei, Luo Sen-Rong, Ouyang Zi-Qi, Chen Zhi-Kai, Liao Xu-Xing, Wu Hao
Department of Neurosurgery, First People's Hospital of Foshan, Foshan, Guangdong, China.
Guangdong Engineering and Technology Research Center for Quality and Efficacy Reevaluation of Post-market Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Front Pharmacol. 2024 Jun 27;15:1402763. doi: 10.3389/fphar.2024.1402763. eCollection 2024.
Naoxintong Capsule (NXT), a renowned traditional Chinese medicine (TCM) formulation, has been broadly applied in China for more than 30 years. Over decades, accumulating evidences have proven satisfactory efficacy and safety of NXT in treating cardiovascular and cerebrovascular diseases (CCVD). Studies have been conducted unceasingly, while this growing latest knowledge of NXT has not yet been interpreted properly and summarized comprehensively. Hence, we systematically review the advancements in NXT research, from its chemical constituents, quality control, pharmacokinetics, to its profound pharmacological activities as well as its clinical applications in CCVD. Moreover, we further propose specific challenges for its future perspectives: 1) to precisely clarify bioactivities of single compound in complicated mixtures; 2) to evaluate the pharmacokinetic behaviors of NXT feature components in clinical studies, especially drug-drug interactions in CCVD patients; 3) to explore and validate its multi-target mechanisms by integrating multi-omics technologies; 4) to re-evaluate the safety and efficacy of NXT by carrying out large-scale, multicenter randomized controlled trials. In brief, this review aims to straighten out a paradigm for TCM modernization, which help to contribute NXT as a piece of Chinese Wisdom into the advanced intervention strategy for CCVD therapy.
脑心通胶囊（NXT）是一种著名的中药制剂，在中国已广泛应用30多年。几十年来，越来越多的证据证明脑心通胶囊在治疗心脑血管疾病（CCVD）方面具有令人满意的疗效和安全性。相关研究一直在不断开展，但关于脑心通胶囊的这些最新知识尚未得到恰当解读和全面总结。因此，我们系统回顾了脑心通胶囊的研究进展，内容涵盖其化学成分、质量控制、药代动力学、其深刻的药理活性以及在CCVD中的临床应用。此外，我们还针对其未来前景提出了具体挑战：1）精确阐明复杂混合物中单一化合物的生物活性；2）在临床研究中评估脑心通胶囊特征成分的药代动力学行为，尤其是CCVD患者中的药物相互作用；3）通过整合多组学技术探索并验证其多靶点机制；4）通过开展大规模、多中心随机对照试验重新评估脑心通胶囊的安全性和疗效。简而言之，本综述旨在梳理出一个中医药现代化的范例，有助于将脑心通胶囊作为中国智慧贡献到CCVD治疗的先进干预策略中。
