Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing 400016, China.
Biomed Res Int. 2018 Dec 18;2018:2815439. doi: 10.1155/2018/2815439. eCollection 2018.
In recent years, the study of metabolomics has begun to receive increasing international attention, especially as it pertains to medical research. This is due in part to the potential for discovery of new biomarkers in the metabolome and to a new understanding of the "exposome", which refers to the endogenous and exogenous compounds that reflect external exposures. Consequently, metabolomics research into pregnancy-related issues has increased. Biomarkers discovered through metabolomics may shed some light on the etiology of certain pregnancy-related complications and their adverse effects on future maternal health and infant development and improve current clinical management. The discoveries and methods used in these studies will be compiled and summarized within the following paper. A further focus of this paper is the use of hair as a biological sample, which is gaining increasing attention across diverse fields due to its noninvasive sampling method and the metabolome stability. Its significance in exposome studies will be considered in this review, as well as the potential to associate exposures with adverse pregnancy outcomes. Currently, hair has been used in only two metabolomics studies relating to fetal growth restriction (FGR) and gestational diabetes mellitus (GDM).
近年来，代谢组学的研究开始受到国际上越来越多的关注，尤其是在医学研究方面。这部分是由于在代谢组中发现新的生物标志物的潜力，以及对“暴露组”的新认识，即反映外部暴露的内源性和外源性化合物。因此，与妊娠相关问题的代谢组学研究有所增加。通过代谢组学发现的生物标志物可能有助于阐明某些与妊娠相关的并发症的病因及其对未来母婴健康和婴儿发育的不良影响，并改善当前的临床管理。这些研究中使用的发现和方法将在以下论文中进行汇编和总结。本文的另一个重点是使用头发作为生物样本，由于其非侵入性的采样方法和代谢组的稳定性，它在各个领域越来越受到关注。本文将考虑头发在暴露组研究中的重要性，以及将暴露与不良妊娠结局联系起来的潜力。目前，头发仅在两项与胎儿生长受限（FGR）和妊娠期糖尿病（GDM）相关的代谢组学研究中使用过。
