Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Gyeonggi-do, Republic of Korea.
Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Gyeonggi-do, Republic of Korea.
Biomed Res Int. 2018 Dec 18;2018:3054316. doi: 10.1155/2018/3054316. eCollection 2018.
Proper management of hyperkalemia that leads to fatal cardiac arrhythmia has become more important because of the increased prevalence of hyperkalemia-prone diseases. Although T-wave changes in hyperkalemia are well known, their usefulness is debatable. We evaluated how well T-wave-based features of electrocardiograms (ECGs) are correlated with estimated serum potassium levels using ECG data from real-world clinical practice.
We collected ECGs from a local ECG repository (MUSE™) from 1994 to 2017 and extracted the ECG waveforms. Of about 1 million reports, 124,238 were conducted within 5 minutes before or after blood collection for serum potassium estimation. We randomly selected 500 ECGs and two evaluators measured the amplitude (T-amp) and right slope of the T-wave (T-right slope) on five lead waveforms (V3, V4, V5, V6, and II). Linear correlations of T-amp, T-right slope, and their normalized feature (T-norm) with serum potassium levels were evaluated using Pearson correlation coefficient analysis.
Pearson correlation coefficients for T-wave-based features with serum potassium between the two evaluators were 0.99 for T-amp and 0.97 for T-right slope. The coefficient for the association between T-amp, T-right slope, and T-norm, and serum potassium ranged from -0.22 to 0.02. In the normal ECG subgroup (normal ECG or otherwise normal ECG), there was no correlation between T-wave-based features and serum potassium level.
T-wave-based features were not correlated with serum potassium level, and their use in real clinical practice is currently limited.
由于易发生高钾血症的疾病患病率增加，对导致致命性心律失常的高钾血症进行适当管理变得更加重要。虽然高钾血症时 T 波改变众所周知，但其用途仍存在争议。我们使用来自真实临床实践的心电图（ECG）数据评估心电图（ECG）中 T 波特征与估计的血清钾水平的相关性。
我们从当地的 ECG 存储库（MUSE™）收集了 1994 年至 2017 年的 ECG 数据，并提取了 ECG 波形。在大约 100 万份报告中，有 124,238 份是在采血进行血清钾估计之前或之后 5 分钟内进行的。我们随机选择了 500 份 ECG，两名评估者在五个导联波形（V3、V4、V5、V6 和 II）上测量 T 波振幅（T-amp）和 T 波右侧斜率（T-right slope）。使用 Pearson 相关系数分析评估 T 波特征与血清钾之间的线性相关性。
两名评估者之间 T 波特征与血清钾之间的 Pearson 相关系数分别为 T-amp 的 0.99 和 T-right slope 的 0.97。T-amp、T-right slope 和 T-norm 与血清钾之间关联的系数范围为-0.22 至 0.02。在正常 ECG 亚组（正常 ECG 或其他正常 ECG）中，T 波特征与血清钾水平之间没有相关性。
T 波特征与血清钾水平不相关，目前在实际临床实践中的应用有限。
