Plat M, Kunze K D, Frank K H, Fleischer J, Koslowski R, Plat U
Abteilung für Hämatologie/Onkologie, Medizinische Akademie, Carl Gustav Carus.
Arch Geschwulstforsch. 1988;58(6):419-30.
The controversy in literature with regard to the origin of Hodgkin's and Reed-Sternberg cells persists, however only two conceptions seem to be plausible at present: the first is based on the relation to histiocytic elements, the second postulates lymphocytic precursors. The significance of surface-markers of these malignant cells in cryostat-sections and in cell-cultures and the relevance of their functional properties are discussed with respect to pathophysiology, clinical appearance, diagnosis and prognosis of Hodgkin's disease. The authors present two tendencies in the classification of malignant lymphomas based on the present knowledge achieved especially by monoclonal antibodies: the first includes aspects of integration between non Hodgkin's lymphomas and Hodgkin's disease, illustrated by the Ki-1-lymphoma, the second is related to separation of entities of the group of Hodgkin's lymphomas (for example the nodular paragranuloma). The aetiopathogenesis of Hodgkin's disease is considered as a causal trinity of virus infection, genetic determination and immunologic predisposition.
关于霍奇金细胞和里德-斯腾伯格细胞的起源，文献中仍存在争议，然而目前似乎只有两种观点看似合理：第一种基于与组织细胞成分的关系，第二种假定为淋巴细胞前体。就霍奇金病的病理生理学、临床表现、诊断和预后而言，讨论了这些恶性细胞在冷冻切片和细胞培养中的表面标志物的意义及其功能特性的相关性。作者基于特别是通过单克隆抗体所获得的现有知识，提出了恶性淋巴瘤分类中的两种趋势：第一种包括非霍奇金淋巴瘤和霍奇金病之间整合的方面，以Ki-1淋巴瘤为例进行说明，第二种与霍奇金淋巴瘤组的实体分离有关（例如结节性副肉芽肿）。霍奇金病的病因发病机制被认为是病毒感染、遗传决定和免疫易感性的因果三联体。
