Lennert K
Arzneimittelforschung. 1987 Feb;37(2A):255-9.
Contrary to the generally accepted dogma that Hodgkin's and non-Hodgkin's lymphomas represent two clearly distinct tumor entities, studies with morphologic and immunological methods revealed many overlappings. Thus Sternberg-Reed cells are not specific to Hodgkin's lymphoma. In addition, the reactivity of the monoclonal antibody Kil, which was developed from Hodgkin cell lines, is by no means restricted to Hodgkin and Sternberg-Reed cells. Moreover, some high grade malignant variants of Hodgkin's lymphoma are morphologically identical to high grade malignant non-Hodgkin's lymphomas. Although the borders between Hodgkin's and non-Hodgkin's lymphoma are often poorly defined, clinical and therapeutic considerations demand that a distinction be attempted whenever possible. It is likely that molecular-genetic methods will enable us to recognize whether and where clear-cut borders exist.
与普遍接受的教条——霍奇金淋巴瘤和非霍奇金淋巴瘤代表两种明显不同的肿瘤实体相反，形态学和免疫学方法研究揭示了许多重叠之处。因此，斯腾伯格-里德细胞并非霍奇金淋巴瘤所特有。此外，从霍奇金细胞系开发的单克隆抗体Kil的反应性绝不仅限于霍奇金细胞和斯腾伯格-里德细胞。而且，霍奇金淋巴瘤的一些高级别恶性变体在形态上与高级别恶性非霍奇金淋巴瘤相同。尽管霍奇金淋巴瘤和非霍奇金淋巴瘤之间的界限常常难以界定，但临床和治疗方面的考虑要求尽可能尝试进行区分。分子遗传学方法可能会使我们能够识别是否以及在何处存在明确的界限。
