Department of Ophthalmology, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Clin Exp Ophthalmol. 2019 Mar;47(2):259-264. doi: 10.1111/ceo.13465. Epub 2019 Feb 14.
The association between visual deficits and attention disorders has been reported but remains unproven.
The objective of this study was to evaluate the risk of attention-deficit hyperactivity disorder (ADHD) in children with amblyopia.
Population-based, cohort study.
The dataset from the Taiwan National Health Insurance Research Database in 2000 to 2010.
A total of 6817 patients aged <18 years with newly diagnosed amblyopia were identified. Four age- and sex-matched controls without amblyopia were included for each patient, that is, 27268 controls.
The primary outcome was the risk of ADHD. The secondary outcomes were age at ADHD onset and use of ADHD medication.
During a mean observation period of 7.18 years, the incidence of ADHD per 1000 person-years was 7.02 in the amblyopia group and 4.61 in the control group (P < 0.0001). The ADHD risk in the amblyopia group was 1.81 times that in the control group (hazard ratio 1.81; 95% confidence interval 1.59-2.06). After stratification by amblyopia subtype, the greatest risk was in the deprivation type (hazard ratio 2.14; 95% confidence interval 1.56-2.92) followed by the strabismic (hazard ratio 2.09; 95% confidence interval 1.15-3.79) and refractive (hazard ratio 1.76; 95% confidence interval 1.54-2.02) types. Age at ADHD onset was younger in the amblyopia group (median 8.14 vs 8.45 years; P = 0.0096). The average duration of neuropsychiatric medication use was comparable between groups (P = 0.98).
The ADHD risk is higher in children with amblyopia.
已经报道了视觉缺陷与注意力障碍之间的关联，但尚未得到证实。
本研究旨在评估弱视儿童发生注意缺陷多动障碍（ADHD）的风险。
基于人群的队列研究。
来自 2000 年至 2010 年台湾全民健康保险研究数据库的数据。
共确定了 6817 名新诊断为弱视的<18 岁患者。为每位患者纳入 4 名年龄和性别匹配的无弱视对照者，即共 27268 名对照者。
主要结局是 ADHD 的风险。次要结局是 ADHD 发病年龄和 ADHD 药物使用。
在平均 7.18 年的观察期内，弱视组每 1000 人年 ADHD 的发病率为 7.02，对照组为 4.61（P<0.0001）。弱视组的 ADHD 风险是对照组的 1.81 倍（风险比 1.81；95%置信区间 1.59-2.06）。按弱视亚型分层后，剥夺型弱视的风险最高（风险比 2.14；95%置信区间 1.56-2.92），其次是斜视型（风险比 2.09；95%置信区间 1.15-3.79）和屈光不正型（风险比 1.76；95%置信区间 1.54-2.02）。弱视组 ADHD 发病年龄较小（中位数 8.14 岁比 8.45 岁；P=0.0096）。两组之间神经精神药物使用的平均持续时间相当（P=0.98）。
弱视儿童发生 ADHD 的风险更高。
Zotero 插件