Stull Carolyn, Grossman Shoshana, Yosipovitch Gil
Department of Dermatology and Itch Center, Lewis Katz School of Medicine at Temple University, 3322 North Broad Street, Medical Office Building, Suite 212, Philadelphia, PA, 19140, USA.
Am J Clin Dermatol. 2016 Dec;17(6):617-624. doi: 10.1007/s40257-016-0213-5.
Pruritus is a common and significant symptom among patients with psoriasis. Pruritus is often present beyond the borders of psoriatic plaques, and frequently affects the scalp and genital regions. Psoriatic itch may be severe and can profoundly affect quality of life and sleep, even in the context of mild-to-moderate disease. These features often make the treatment of psoriatic pruritus challenging. However, there are a variety of effective topical and systemic treatment modalities available to address this symptom. While there remains a need for treatments that specifically target psoriatic itch, newly licensed therapies including secukinumab, ixekizumab and apremilast have been shown to rapidly and effectively mediate itch reduction.
瘙痒是银屑病患者常见且重要的症状。瘙痒常出现在银屑病斑块边界之外，且经常累及头皮和生殖器区域。即使在轻度至中度病情的情况下，银屑病瘙痒也可能很严重，会对生活质量和睡眠产生深远影响。这些特征常常使银屑病瘙痒的治疗具有挑战性。然而，有多种有效的局部和全身治疗方法可用于解决这一症状。虽然仍需要专门针对银屑病瘙痒的治疗方法，但已证明包括司库奇尤单抗、依奇珠单抗和阿普米司特在内的新获批疗法能迅速有效地减轻瘙痒。
