Stäb Daniel, Al Najjar Aiman, O'Brien Kieran, Strugnell Wendy, Richer Jonathan, Rieger Jan, Niendorf Thoralf, Barth Markus
The Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia; Department of Diagnostic and Interventional Radiology, University Clinic Würzburg, Würzburg, Germany;
The Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia.
J Vis Exp. 2019 Jan 6(143). doi: 10.3791/55853.
CMR at an ultra-high field (magnetic field strength B0 ≥ 7 Tesla) benefits from the signal-to-noise ratio (SNR) advantage inherent at higher magnetic field strengths and potentially provides improved signal contrast and spatial resolution. While promising results have been achieved, ultra-high field CMR is challenging due to energy deposition constraints and physical phenomena such as transmission field non-uniformities and magnetic field inhomogeneities. In addition, the magneto-hydrodynamic effect renders the synchronization of the data acquisition with the cardiac motion difficult. The challenges are currently addressed by explorations into novel magnetic resonance technology. If all impediments can be overcome, ultra-high field CMR may generate new opportunities for functional CMR, myocardial tissue characterization, microstructure imaging or metabolic imaging. Recognizing this potential, we show that multi-channel radio frequency (RF) coil technology tailored for CMR at 7 Tesla together with higher order B0 shimming and a backup signal for cardiac triggering facilitates high fidelity functional CMR. With the proposed setup, cardiac chamber quantification can be accomplished in examination times similar to those achieved at lower field strengths. To share this experience and to support the dissemination of this expertise, this work describes our setup and protocol tailored for functional CMR at 7 Tesla.
超高场(磁场强度B0≥7特斯拉)心脏磁共振成像(CMR)受益于较高磁场强度固有的信噪比(SNR)优势,并有可能提供更好的信号对比度和空间分辨率。虽然已经取得了令人鼓舞的成果,但由于能量沉积限制以及诸如传输场不均匀性和磁场不均匀性等物理现象,超高场CMR具有挑战性。此外,磁流体动力学效应使得数据采集与心脏运动的同步变得困难。目前,通过探索新型磁共振技术来应对这些挑战。如果所有障碍都能被克服,超高场CMR可能为功能性CMR、心肌组织表征、微观结构成像或代谢成像带来新的机遇。认识到这一潜力,我们表明,专为7特斯拉CMR量身定制的多通道射频(RF)线圈技术,结合高阶B0匀场和心脏触发备用信号,有助于实现高保真功能性CMR。采用所提出的设置,可以在与低场强检查时间相似的情况下完成心腔定量分析。为了分享这一经验并支持这种专业知识的传播,本文描述了我们专为7特斯拉功能性CMR量身定制的设置和方案。