精氨酸-赖氨酸-天冬氨酸-缬氨酸-酪氨酸（胸腺五肽）可加速胆碱能诱导的重组烟碱型受体失活（脱敏）。
Arg-Lys-Asp-Val-Tyr (thymopentin) accelerates the cholinergic-induced inactivation (desensitization) of reconstituted nicotinic receptor.
作者信息
Ochoa E L, Medrano S, de Carlin M C, Dilonardo A M
机构信息
Instituto de Biologia Celular, Facultad de Medicina UBA, Argentina.
出版信息
Cell Mol Neurobiol. 1988 Sep;8(3):325-31. doi: 10.1007/BF00711174.
Abstract
- The thymic hormone thymopoietin blocks neuromuscular transmission and was proposed (Goldstein, 1974) as a modulator of synaptic conductivity. 2. The cholinergic-induced inactivation of nicotinic receptor reconstituted into asolectin lipid vesicles was studied in the presence and in the absence of thymopentin, a synthetic pentapeptide corresponding to positions 32-36 of thymopoietin. 3. The present data show that thymopentin accelerates desensitization of the nicotinic acetylcholine receptor, supporting the aforementioned physiological role proposed for thymopoietin. 4. They also suggest that the hormone itself and/or a yet unidentified hormine-derived peptide fragment may act as an endogenous ligand for nicotinic acetylcholine receptor desensitization.
摘要
- 胸腺激素促胸腺生成素可阻断神经肌肉传递，（戈尔茨坦，1974年）曾有人提出它作为突触传导性的调节剂。2. 在有和没有胸腺五肽（一种对应于促胸腺生成素第32 - 36位的合成五肽）存在的情况下，研究了胆碱能诱导的重组到大豆卵磷脂脂质小泡中的烟碱样受体的失活情况。3. 目前的数据表明，胸腺五肽可加速烟碱样乙酰胆碱受体的脱敏，支持了上述提出的促胸腺生成素的生理作用。4. 这些数据还表明，该激素本身和/或一个尚未鉴定的激素衍生肽片段可能作为烟碱样乙酰胆碱受体脱敏的内源性配体。
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Arg-Lys-Asp-Val-Tyr (thymopentin) accelerates the cholinergic-induced inactivation (desensitization) of reconstituted nicotinic receptor.精氨酸-赖氨酸-天冬氨酸-缬氨酸-酪氨酸（胸腺五肽）可加速胆碱能诱导的重组烟碱型受体失活（脱敏）。
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本文引用的文献
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Complete amino acid sequences of bovine thymopoietins I, II, and III: closely homologous polypeptides.牛胸腺生成素I、II和III的完整氨基酸序列：密切同源的多肽。
Biochemistry. 1981 Oct 13;20(21):6195-200. doi: 10.1021/bi00524a044.
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Effects of thio-group modifications on the ion permeability control and ligand binding properties of Torpedo californica acetylcholine receptor.硫醇基团修饰对加州电鳐乙酰胆碱受体离子通透性调控及配体结合特性的影响。
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