胸腺素（一种纯化的胸腺多肽激素）在体外诱导T细胞分化。
Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus.
作者信息
Basch R S, Goldstein G
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1474-8. doi: 10.1073/pnas.71.4.1474.
Abstract
Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (theta)] when incubated in vitro with mouse bone marrow or spleen cells. This induction occurred in 5-10% of the cells from bone marrow after a 2-hr incubation with subnanogram concentrations of thymin. The induced cells expressed more TL and Thy-1 (theta) antigens than average normal thymocytes.
摘要
胸腺素是一种从牛胸腺中分离出来的纯化多肽，当与小鼠骨髓或脾细胞在体外孵育时，它能诱导胸腺细胞特有的分化抗原[TL和Thy-1（θ）]的表达。在与亚纳克浓度的胸腺素孵育2小时后，骨髓来源的细胞中有5%-10%发生了这种诱导。诱导后的细胞表达的TL和Thy-1（θ）抗原比正常胸腺细胞平均水平更多。
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Experimental myasthenia in mice. The role of the thymus and lymphoid cells.小鼠实验性肌无力。胸腺和淋巴细胞的作用。
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