牛胸腺生成素I、II和III的完整氨基酸序列：密切同源的多肽。

Complete amino acid sequences of bovine thymopoietins I, II, and III: closely homologous polypeptides.

作者信息

Audhya T, Schlesinger D H, Goldstein G

出版信息

Biochemistry. 1981 Oct 13;20(21):6195-200. doi: 10.1021/bi00524a044.

Abstract

Complete amino acid sequences were determined for thymopoietins I and II (revision), isolated from bovine thymus, and for thymopoietin III, a newly identified polypeptide isolated from bovine spleen. Thymopoietin III (TP-III) is a 49 amino acid monomeric peptide that shows minor microheterogeneity at residue 34. The three thymopoietins have largely identical sequences yet some distinct differences, suggesting very recent evolution from a common gene. The complete amino acid sequences are (Formula: see text).

摘要

已测定了从牛胸腺中分离出的胸腺生成素I和II（修订版）以及从牛脾脏中分离出的新鉴定多肽胸腺生成素III的完整氨基酸序列。胸腺生成素III（TP-III）是一种由49个氨基酸组成的单体肽，在第34位残基处表现出微小的微异质性。这三种胸腺生成素的序列基本相同，但也存在一些明显差异，表明它们是由一个共同基因最近进化而来的。完整的氨基酸序列如下（公式：见正文）。