肿瘤坏死因子受体 1 相关死亡结构域蛋白是急性髓系白血病的一个潜在预后生物标志物。

Tumor Necrosis Factor Receptor Type 1-Associated Death Domain Protein Is a Potential Prognostic Biomarker in Acute Myeloid Leukemia.

机构信息

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Am J Med Sci. 2019 Feb;357(2):111-115. doi: 10.1016/j.amjms.2018.10.015. Epub 2018 Nov 20.

DOI:10.1016/j.amjms.2018.10.015

PMID:30665491

Abstract

BACKGROUND

Tumor necrosis factor receptor type 1-associated death domain protein (TRADD) mediates programmed cell death signaling as well as the Fas-induced cell death pathway. The downregulation of TRADD is found to be associated with the occurrence of many cancers. The present study was designed to investigate the association between TRADD and clinicopathologic features as well as its clinical significance in acute myeloid leukemia (AML).

METHODS

Real-time polymerase chain reaction was performed in 100 new AML, 23 AML complete remission patients, and 20 normal individuals. All statistical analysis was performed using SPSS software.

RESULTS

It was found that the expression of TRADD messenger RNA was lower in new AML patients as compared to healthy individuals and complete remission patients (P = 0.00239). Moreover, TRADD messenger RNA levels were associated with clinical factors such as risk classification (P = 0.0023) and complete remission (P = 0.0147). Kaplan-Meier analysis revealed that the AML patients with high TRADD expression had significantly prolonged overall survival and higher complete remission compared with low TRADD expressing patients.

CONCLUSIONS

It is concluded that downregulation of TRADD may be an independent potential prognostic biomarker in AML.

摘要

背景

肿瘤坏死因子受体相关死亡结构域蛋白（TRADD）介导程序性细胞死亡信号以及 Fas 诱导的细胞死亡途径。TRADD 的下调与许多癌症的发生有关。本研究旨在探讨 TRADD 与临床病理特征的关系及其在急性髓细胞白血病（AML）中的临床意义。

方法

对 100 例新诊断的 AML 患者、23 例 AML 完全缓解患者和 20 例正常个体进行实时聚合酶链反应。所有统计分析均使用 SPSS 软件进行。

结果

发现新诊断的 AML 患者中 TRADD 信使 RNA 的表达低于健康个体和完全缓解患者（P=0.00239）。此外，TRADD 信使 RNA 水平与风险分类（P=0.0023）和完全缓解（P=0.0147）等临床因素相关。Kaplan-Meier 分析显示，高 TRADD 表达的 AML 患者的总生存期明显延长，完全缓解率高于低 TRADD 表达的患者。