TRPC6 在糖尿病肾病中的作用：是好是坏？
TRPC6 in diabetic kidney disease: good guy or bad guy?
机构信息
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA.
出版信息
Kidney Int. 2019 Feb;95(2):256-258. doi: 10.1016/j.kint.2018.10.027.
An association of altered activity of transient receptor potential cation channel C6 (TRPC6) with the development of various diabetic complications was previously reported. In this issue, Wang et al. tested the contribution of TRPC6 in type 1 diabetes setting by breeding Akita mice with TRPC6 knockout mice. The authors revealed that the knockout of TRPC6 decreased proteinuria and attenuated tubule injury but promoted mesangial expansion in Akita mice. Therefore, TRPC6 has both beneficial and detrimental effects on glomeruli function.
先前有报道称，瞬时受体电位阳离子通道 C6（TRPC6）的活性改变与各种糖尿病并发症的发展有关。在本期杂志中，Wang 等人通过将 TRPC6 敲除小鼠与 Akita 小鼠杂交，检测了 TRPC6 在 1 型糖尿病发病机制中的作用。作者发现，TRPC6 敲除可减少蛋白尿并减轻肾小管损伤，但促进 Akita 小鼠系膜扩张。因此，TRPC6 对肾小球功能既有有益作用，也有有害作用。
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