Yuki Katsuyuki, Kawano Sawako, Mori Shinobu, Murase Takatoshi
Biological Science Laboratories, Kao Corporation, Ichikai-machi, Haga-gun, Tochigi, Japan,
Clin Cosmet Investig Dermatol. 2019 Jan 11;12:63-69. doi: 10.2147/CCID.S183764. eCollection 2019.
The transdermal application of carbon dioxide (CO) gas dissolved in a solution and bathing in carbonated springs have been known to improve circulatory disorders. We aimed to elucidate and profile the effects of CO application on local skin function.
A liquid formulation that included high-concentration CO or a control formulation was applied to the face of healthy men for 8 weeks. Quantitative analysis was performed during the dry winter months.
At the site where the control formulation was applied, transepidermal water loss (TEWL) increased while the moisturizing function (conductance) of facial skin decreased during the study period. However, at the CO-treated site, increases in TEWL and decreases in conductance were significantly suppressed. In addition, the deterioration in scaliness and wrinkles parameters were suppressed by ≥40% at the CO-treated site. There were no significant differences in skin surface pH or color properties between the control and test sites.
This study suggests that the continuous application of a high-concentration CO formulation can affect skin physiology and has the potential to suppress reductions in the barrier and moisturizing functions of the stratum corneum accompanied by desquamation, which occurs during the winter.
已知将溶解在溶液中的二氧化碳（CO₂）经皮应用以及泡碳酸温泉可改善循环系统紊乱。我们旨在阐明并描述CO₂应用对局部皮肤功能的影响。
将包含高浓度CO₂的液体制剂或对照制剂应用于健康男性的面部，为期8周。在干燥的冬季进行定量分析。
在应用对照制剂的部位，在研究期间经表皮水分流失（TEWL）增加，而面部皮肤的保湿功能（电导）下降。然而，在CO₂处理部位，TEWL的增加和电导的下降得到了显著抑制。此外，在CO₂处理部位，鳞屑和皱纹参数的恶化被抑制了≥40%。对照部位和测试部位之间的皮肤表面pH值或颜色特性没有显著差异。
本研究表明，持续应用高浓度CO₂制剂可影响皮肤生理，并有可能抑制冬季发生的伴有脱屑的角质层屏障和保湿功能的降低。
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