心脏生理学和病理学的实验模型。
Experimental models of cardiac physiology and pathology.
机构信息
Icahn School of Medicine at Mount Sinai, New York, USA.
Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, #1030, New York, NY, 10029, USA.
出版信息
Heart Fail Rev. 2019 Jul;24(4):601-615. doi: 10.1007/s10741-019-09769-2.
Abstract
Experimental models of cardiac disease play a key role in understanding the pathophysiology of the disease and developing new therapies. The features of the experimental models should reflect the clinical phenotype, which can have a wide spectrum of underlying mechanisms. We review characteristics of commonly used experimental models of cardiac physiology and pathophysiology in all translational steps including in vitro, small animal, and large animal models. Understanding their characteristics and relevance to clinical disease is the key for successful translation to effective therapies.
摘要
心脏疾病的实验模型在理解疾病的病理生理学和开发新疗法方面发挥着关键作用。实验模型的特征应反映临床表型，其潜在机制具有广泛的谱。我们回顾了所有转化步骤中常用的心脏生理学和病理生理学实验模型的特征，包括体外、小动物和大动物模型。了解它们的特征以及与临床疾病的相关性是将其成功转化为有效治疗方法的关键。
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