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透析依赖的慢性肾脏病患者在重症监护病房的资源利用和结局。

Resource use and outcomes in patients with dialysis-dependent chronic kidney disease admitted to intensive care.

机构信息

Department of Intensive Care, Alice Springs Hospital, Alice Springs, Northern Territory, Australia.

School of Medicine, Flinders University, Adelaide, South Australia, Australia.

出版信息

Intern Med J. 2019 Oct;49(10):1252-1261. doi: 10.1111/imj.14232.

Abstract

BACKGROUND

Central Australia (CA) has a high prevalence of haemodialysis-dependent chronic kidney disease (CKD5D). CKD5D is associated with an increased need for critical care services.

AIMS

To describe the demographic features, critical care resource use and outcomes of patients with CKD5D requiring intensive care admission in CA.

METHODS

Retrospective matched cohort database study. Patients with CKD5D who required admission for critical illness between 1 July 2015 and 30 June 2016 were identified using the Centre for Outcome and Resource Evaluation Outcome Measurement and Evaluation Tool (CORE COMET) and matched with patients without CKD5D. The primary outcome was all cause mortality. Secondary outcomes explored use of critical care and other ongoing healthcare use.

RESULTS

There were 621 critical care admissions during the study period. Of these, CKD5D patients comprised 88 admissions (14%), representing 63 patients. Compared to matched controls, these patients had a similar mortality at a median follow up of 463 days (17% vs 22%, P = 0.50) which did not change when patients with an intensive care unit length of stay (ICU LoS) less than 4 days were excluded. CKD5D patients had a shorter median ICU LoS (1.3 vs 2.9). Although those with CKD5D had higher healthcare resource use, the rate of utilisation remained unchanged by their ICU admission.

CONCLUSIONS

This retrospective observational matched cohort study examining the burden of disease amongst CKD5D patients in CA suggests that there is no additional mortality burden in this group, nor do they require significantly higher critical care resources compared to a matched cohort.

摘要

背景

澳大利亚中部(CA)地区血液透析依赖的慢性肾脏病(CKD5D)的发病率很高。CKD5D 与对重症监护服务的需求增加有关。

目的

描述需要重症监护入院的 CA 地区 CKD5D 患者的人口统计学特征、重症监护资源使用情况和结局。

方法

回顾性匹配队列数据库研究。使用中心结果和资源评估结果测量和评估工具(CORE COMET)识别在 2015 年 7 月 1 日至 2016 年 6 月 30 日期间因重症疾病需要入院的 CKD5D 患者,并与没有 CKD5D 的患者进行匹配。主要结局是全因死亡率。次要结局探讨了重症监护和其他持续医疗保健的使用情况。

结果

在研究期间,共有 621 例重症监护入院。其中,CKD5D 患者有 88 例(14%),代表 63 名患者。与匹配的对照组相比,这些患者在中位数为 463 天的随访中死亡率相似(17%比 22%,P = 0.50),当排除 ICU 住院时间(ICU LoS)少于 4 天的患者时,死亡率没有变化。CKD5D 患者的 ICU LOS 中位数更短(1.3 比 2.9)。尽管 CKD5D 患者的医疗资源使用率较高,但 ICU 入院并未改变其使用率。

结论

这项对 CA 地区 CKD5D 患者疾病负担的回顾性观察性匹配队列研究表明,该组患者没有额外的死亡负担,与匹配队列相比,他们也不需要明显更高的重症监护资源。

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