高剂量率近距离放射治疗后鼻平面鳞状细胞癌猫的预后因素
Prognostic factors for cats with squamous cell carcinoma of the nasal planum following high-dose rate brachytherapy.
作者信息
Lino Mafalda, Lanore Didier, Lajoinie Mathilde, Jimenez Ana, Crouzet Franck, Queiroga Felisbina L
机构信息
Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
Veterinary Clinic Alliance, Bordeaux, France.
出版信息
J Feline Med Surg. 2019 Dec;21(12):1157-1164. doi: 10.1177/1098612X18822409. Epub 2019 Jan 22.
OBJECTIVES
The aim of the study was to investigate retrospectively the prognostic impact of variables such as sex, neuter status, breed, age, number of lesions, location and size of the tumour, tumour extension beyond the nasal planum, ulceration and lymph node status, among others, in a population of cats treated with high-dose rate brachytherapy.
METHODS
This study reviews the outcome of 58 cats with cytologically and/or histologically confirmed squamous cell carcinoma of the nasal planum, treated at the Clinic Alliance (Bordeaux, France) with high-dose rate brachytherapy from 2010-2016. The total radiation dose delivered was 30 Gy, administered in two different schedules: five fractions of 6 Gy for a period of 4 days (Tuesday-Friday) or four fractions of 7.5 Gy for a period of 3 days (Tuesday- Thursday). Data were collected from cats' clinical records.
RESULTS
Complete response was achieved in 72% (n = 36) of the cats, partial response in 24% (n = 13) and 2% (n = 1) did not respond. Median progression-free survival and overall survival times were 316 and 835 days, respectively.
CONCLUSIONS AND RELEVANCE
Results indicated that sex ( = 0.045), extension of the tumour from the nasal planum to the upper lip ( = 0.015), tumour size ( = 0.015; = 0.001), the existence of a previous treatment ( = 0.043) and the tumour response to high-dose rate brachytherapy ( = 0.038; <0.001) are prognostic factors for cats with squamous cell carcinoma of the nasal planum following high-dose rate brachytherapy.
目的
本研究旨在回顾性调查在接受高剂量率近距离放射治疗的猫群体中，性别、绝育状态、品种、年龄、病变数量、肿瘤位置和大小、肿瘤超出鼻平面的范围、溃疡和淋巴结状态等变量的预后影响。
方法
本研究回顾了2010年至2016年在法国波尔多临床联盟接受高剂量率近距离放射治疗的58只经细胞学和/或组织学确诊为鼻平面鳞状细胞癌的猫的治疗结果。总放射剂量为30 Gy，采用两种不同的方案给药：6 Gy分五次，在4天内（周二至周五）给予；或7.5 Gy分四次，在3天内（周二至周四）给予。数据从猫的临床记录中收集。
结果
72%（n = 36）的猫实现了完全缓解，24%（n = 13）部分缓解，2%（n = 1）无反应。无进展生存期和总生存期的中位数分别为316天和835天。
结论及相关性
结果表明，性别（P = 0.045）、肿瘤从鼻平面延伸至上唇（P = 0.015）、肿瘤大小（P = 0.015；P = 0.001）、既往治疗情况（P = 0.043）以及肿瘤对高剂量率近距离放射治疗的反应（P = 0.038；P <0.001）是高剂量率近距离放射治疗后鼻平面鳞状细胞癌猫的预后因素。
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