AniCura Glòries Hospital Veterinari, Barcelona, Spain.
J Feline Med Surg. 2024 Jul;26(7):1098612X241248043. doi: 10.1177/1098612X241248043.
Squamous cell carcinoma (SCC) is the most common tumour in the nasal planum of cats. Surgery has traditionally been the treatment of choice but might not be feasible in locally advanced scenarios. Electrochemotherapy (ECT) has shown good control in superficial tumours, but there is a lack of robust information about efficacy in locally advanced cases. The aim of this study was to assess the safety and efficacy of ECT in the treatment of locally advanced stage nasal planum SCC in cats.
The clinical database of a veterinary referral hospital was searched retrospectively for cats diagnosed with a locally advanced nasal planum SCC (TNM or TNM) that had received ECT. Local response, adverse events and outcome were documented. The data were evaluated by inferential statistics and correlations between response, recurrence, feline immunodeficiency virus/feline leukaemia virus status, number of treatments, voltage and severity of adverse events, with Kaplan-Meier curves and log-rank tests. Statistical significance was set at <0.05.
In total, 21 cats were enrolled over a 4-year period. Nineteen cats achieved a complete response (CR) and two cats a partial response (PR) for an overall response rate of 100%. Cats achieving a CR had a median disease-free interval of 182 days (range 128-327) and those with a PR had a median progression-free survival of 156.5 days (range 122-191). The median time to progression was not reached. The overall survival was 453 days for a median follow-up of 341 days (range 191-989). Of the cats, 62% had grade 3 or 4 toxicities, but no deaths due to the treatment were documented. Only voltage was correlated with longer survival ( = 0.001).
ECT appears to be an effective treatment for feline nasal planum SCC and could be considered a first-line therapy for locally advanced cases. Toxicities reported can be severe in the short term and these could be secondary to more invasive lesions and equipment used.
鳞状细胞癌（SCC）是猫鼻平面最常见的肿瘤。手术一直是首选治疗方法，但在局部晚期情况下可能不可行。电化学疗法（ECT）已显示出对浅表肿瘤的良好控制，但缺乏关于局部晚期病例疗效的可靠信息。本研究旨在评估 ECT 治疗猫局部晚期鼻平面 SCC 的安全性和疗效。
回顾性搜索一家兽医转诊医院的临床数据库，以寻找诊断为局部晚期鼻平面 SCC（TNM 或 TNM）并接受 ECT 治疗的猫。记录局部反应、不良事件和结果。通过推断统计学和反应、复发、猫免疫缺陷病毒/猫白血病病毒状态、治疗次数、电压和不良事件严重程度之间的相关性，对数据进行评估，采用 Kaplan-Meier 曲线和对数秩检验。统计学意义设为 <0.05。
在 4 年期间共纳入 21 只猫。19 只猫完全缓解（CR），2 只猫部分缓解（PR），总缓解率为 100%。CR 的猫无疾病间隔中位数为 182 天（范围 128-327），PR 的猫无进展生存期中位数为 156.5 天（范围 122-191）。未达到进展时间中位数。中位随访 341 天（范围 191-989）的总生存率为 453 天。在这些猫中，62%有 3 级或 4 级毒性，但没有因治疗而死亡的病例。只有电压与更长的生存时间相关（=0.001）。
ECT 似乎是猫鼻平面 SCC 的有效治疗方法，可考虑作为局部晚期病例的一线治疗方法。短期报告的毒性可能很严重，这可能是由于更具侵袭性的病变和使用的设备所致。
