Gasymova Evgeniya, Meier Valeria, Guscetti Franco, Cancedda Simona, Roos Malgorzata, Rohrer Bley Carla
Division of Radiation Oncology, Vetsuisse-Faculty, University of Zurich, CH-8057, Zurich, Switzerland.
Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, CH-8057, Zurich, Switzerland.
BMC Vet Res. 2017 Apr 4;13(1):86. doi: 10.1186/s12917-017-1018-3.
Cutaneous squamous cell carcinoma of the nasal planum in cats is a common indication for antitumor treatment such as external beam radiation therapy. Curative-intent radiation therapy has been described as a valuable treatment option, resulting in long and stable tumor control in these patients. The aim of the current study was to evaluate outcome and toxicity, as well as possible prognostic factors using an accelerated hypofractionated radiation therapy protocol. Cats with squamous cell carcinoma of the nasal planum treated with an accelerated radiation protocol (10 × 4.8 Gy, over one week) were retrospectively evaluated. Tumor- and treatment-associated variables were evaluated in respect to local control and survival.
Forty-four cats met the inclusion criteria for this study. All cats showed complete response to therapy. Median disease-free interval (DFI) for all cases was 916 days (95% CI: 456-1377). One- and two-year DFIs were 71% (95% CI: 56-86%) and 60% (95% CI: 43-77%). Of the tested variables, only tumor volume showed a tendency to influence DFI, with larger tumors having a 5.4 times greater risk of recurrence than the smaller ones (HR 1.33 (95% CI: 0.99-1.79), p = 0.054). Median overall survival (OS) was 902 days (95% CI: 862-942). One- and 2-year OSs were 79.3% (95% CI: 67.3-91.3) and 58.4% (95% CI: 42.8-74). Of the tested variables, again, only tumor volume influenced OS with larger tumors having a 6.3 times greater risk of dying than the smaller ones (HR 1.36 (95% CI: 1.07-1.73), p = 0.010). The acute and late toxicity profile was low and hence clinically acceptable.
Curative-intent radiation therapy with an accelerated fractionation schedule can be considered a safe, cosmetically superior treatment option for cutaneous squamous cell carcinomas of the nasal planum in cats, resulting in long and stable tumor control.
猫鼻平面皮肤鳞状细胞癌是抗肿瘤治疗（如外照射放疗）的常见适应症。根治性放疗已被描述为一种有价值的治疗选择，可使这些患者实现长期稳定的肿瘤控制。本研究的目的是使用加速分割放疗方案评估疗效和毒性，以及可能的预后因素。对采用加速放疗方案（10×4.8 Gy，为期一周）治疗的猫鼻平面鳞状细胞癌进行回顾性评估。评估肿瘤和治疗相关变量与局部控制和生存的关系。
44只猫符合本研究的纳入标准。所有猫对治疗均显示完全缓解。所有病例的中位无病间期（DFI）为916天（95%CI：456 - 1377）。1年和2年无病生存率分别为71%（95%CI：56 - 86%）和60%（95%CI：43 - 77%）。在所有检测变量中，只有肿瘤体积显示出影响无病间期的趋势，较大肿瘤复发风险比较小肿瘤高5.4倍（风险比1.33（95%CI：0.99 - 1.79），p = 0.054）。中位总生存期（OS）为902天（95%CI：862 - 942）。1年和2年总生存率分别为79.3%（95%CI：67.3 - 91.3）和58.4%（95%CI：42.8 - 74）。同样，在所有检测变量中只有肿瘤体积影响总生存期，较大肿瘤死亡风险比较小肿瘤高6.3倍（风险比1.36（95%CI：1.07 - 1.73），p = 0.010）。急性和晚期毒性反应较低，因此在临床上可以接受。
加速分割放疗方案的根治性放疗可被认为是治疗猫鼻平面皮肤鳞状细胞癌的一种安全、美容效果更佳的治疗选择，可实现长期稳定的肿瘤控制。
