从大白杜鹃的叶和嫩枝中分离得到一种新的抗坏血酸衍生物和两种新的萜类化合物。
A new ascorbic acid derivative and two new terpenoids from the leaves and twigs of Rhododendron decorum.
作者信息
Zhu Yu-Xun, Zhang Zhao-Xin, Zhang Huan-Ping, Chai Li-Sha, Li Li, Ma Shuang-Gang, Li Yong
机构信息
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, China.
出版信息
J Asian Nat Prod Res. 2019 Jun;21(6):579-586. doi: 10.1080/10286020.2018.1561669. Epub 2019 Jan 22.
The phytochemical study of the ethanol extract of the leaves and twigs of Rhododendron decorum afforded a new ascorbic acid derivative (1), a new ionone analogue (2), a new ursane-type triterpenoid glucoside (3), and four known compounds (4-7). The structures were elucidated by spectroscopic analyses, including HRESIMS, 1D, and 2D NMR. The anti-neuroinflammatory activities of the compounds were evaluated by measuring inhibitory effects of LPS-induced NO production in BV2 cells.
对大白杜鹃叶和嫩枝乙醇提取物进行的植物化学研究得到了一种新的抗坏血酸衍生物（1）、一种新的紫罗兰酮类似物（2）、一种新的乌苏烷型三萜糖苷（3）以及四种已知化合物（4 - 7）。通过包括高分辨电喷雾电离质谱（HRESIMS）、一维和二维核磁共振（NMR）在内的光谱分析确定了这些化合物的结构。通过测量化合物对脂多糖（LPS）诱导的BV2细胞中一氧化氮（NO）生成的抑制作用，评估了这些化合物的抗神经炎症活性。
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