从 L. 的叶子中分离得到的一种新的五环三萜，具有抑制 LPS 诱导的 RAW 264.7 细胞中 NO 产生的作用。
A new pentacyclic triterpenoid from the leaves of L. with inhibition of NO production in LPS-induced RAW 264.7 cells.
机构信息
Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules Ministry of Education, Yanbian University College of Pharmacy, Yanji, P. R. China.
Department of Pharmacy, Yanbian University Hospital, Yanji, P. R. China.
出版信息
Nat Prod Res. 2020 Dec;34(23):3313-3319. doi: 10.1080/14786419.2019.1566822. Epub 2019 Feb 27.
A new pentacyclic triterpenoid, 3-oxo-urs-11,13(18)-dien-28-oic acid (), along with twelve known triterpenoids, -amyrin (), 19-hydroxy--amyrin (), triptohypol E (), uvaol (), 2,3-dihydroxyurs-11-en-13,28-olide (), 3-hydroxyurs-11-en-13,28-olide (), ursolic acid (), asiatic acid (), oleanolic acid (), aegiceradienol (), obtusalin () and betulinic acid () were isolated from the leaves of L. Their structures were established from spectroscopic data and comparison with reported values. Among them, compounds , , , and were isolated from the Ericaceae family for the first time. Compounds , , , and were obtained from for the first time. Additionally, compounds , and significantly inhibited the levels of NO in LPS-stimulated RAW 264.7 cells at 3 μM.
一种新的五环三萜，3-氧代-urs-11,13(18)-二烯-28-酸（），以及十二种已知的三萜，-齐墩果酸（）、19-羟基--齐墩果酸（）、三萜醇 E（）、乌苏酸（）、2,3-二羟基乌苏-11-烯-13,28-内酯（）、3-羟基乌苏-11-烯-13,28-内酯（）、熊果酸（）、齐墩果酸（）、齐墩果酸（）、aegiceradienol（）、obtusalin（）和白桦脂酸（），从柳叶菜科的叶子中分离出来。它们的结构是根据光谱数据和与报道值的比较确定的。其中，化合物、、、和是首次从杜鹃花科中分离得到的。化合物、、、和是首次从柳叶菜中分离得到的。此外，化合物、和在 3 μM 时显著抑制 LPS 刺激的 RAW 264.7 细胞中 NO 的水平。
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