Compston A
Department of Neurology, University of Wales College of Medicine, Heath Park, Cardiff, UK.
J Neurol Neurosurg Psychiatry. 1988 Oct;51(10):1249-52. doi: 10.1136/jnnp.51.10.1249.
The clinical and pathological features of multiple sclerosis were fully described, in France and subsequently in England, during the latter half of the XIXth century but clinical descriptions, personal accounts and depictions of the disease had appeared at various times over the previous 50 years. Jean Cruveilhier is usually credited with having first illustrated the lesions of multiple sclerosis in the second tome of his pathological atlas which bears the title date 1835. But the 40 livraisons which make up this work were published separately in parts and documentary evidence contained within the second volume indicates that the putative case of multiple sclerosis cannot have appeared earlier than 1841. Robert Carswell also may have published his pathological atlas in parts but the work was completed by 1838 and so his depiction of the lesions of multiple sclerosis, appearing on plate 4 fig 1, predates Cruveilhier's by at least three years. Curiously, Carswell and Cruveilhier each observed their pathological material in Paris but they cannot have depicted the same individual. 1988 is therefore the 150th anniversary of the depiction of the lesions of multiple sclerosis; the unnamed patient was French, the illustrator a Scotsman.
19世纪后半叶，法国以及随后的英国充分描述了多发性硬化症的临床和病理特征，但在之前的50年里，该病的临床描述、个人记录和相关描绘曾在不同时期出现过。让·克鲁维耶通常被认为是首个在其病理图谱第二卷中描绘多发性硬化症病变的人，该图谱的标题日期为1835年。但构成这部著作的40个分册是分批出版的，第二卷中的文献证据表明，该疑似多发性硬化症病例不可能早于1841年出现。罗伯特·卡斯韦尔也可能是分批出版了他的病理图谱，但这项工作在1838年完成，因此他在第4版图1中对多发性硬化症病变的描绘比克鲁维耶的至少早三年。奇怪的是，卡斯韦尔和克鲁维耶都在巴黎观察了他们的病理材料，但他们描绘的不可能是同一个人。因此，1988年是描绘多发性硬化症病变的150周年；这位未具名的患者是法国人，绘图者是苏格兰人。
