From the Department of Neurology (H.C.L.), University of Cologne, Germany; Department of Clinical Neurosciences (A.C.), University of Cambridge Medical School, UK; and Department of Neurology, Medical Faculty (H.-P.H.), Heinrich-Heine University Düsseldorf, Germany.
Neurology. 2018 May 29;90(22):1011-1016. doi: 10.1212/WNL.0000000000005613.
The clinical features of multiple sclerosis were first defined in detail and with pathologic confirmation in a medical thesis published at the Salpêtrière, Paris, in 1868. The author, Leopold Ordenstein (1835-1902), a German physician, analyzed cases collected by his mentor, Jean-Martin Charcot (1825-1893). The 2 clinician-scientists described the characteristic symptoms, predisposing age, and pathologic features of the disease, and emphasized the clear delineation from other chronic progressive disorders, especially paralysis agitans. The latter was referred to as Parkinson disease by William Sanders in 1865 and adopted by Désiré-Magloire Bourneville on behalf of Charcot in 1875. This essay commemorates the 150th anniversary of the publication of the pioneering work of Leopold Ordenstein and Jean-Martin Charcot.
多发性硬化症的临床特征首先在 1868 年巴黎萨尔佩特里埃的一篇医学论文中被详细定义并得到病理证实。作者利奥波德·奥登斯坦（Leopold Ordenstein，1835-1902）是一位德国医生，他分析了导师让-马丁·沙尔科（Jean-Martin Charcot，1825-1893）收集的病例。这两位临床科学家描述了这种疾病的典型症状、易患年龄和病理特征，并强调了它与其他慢性进行性疾病的明显区别，尤其是震颤麻痹症。震颤麻痹症于 1865 年被威廉·桑德斯（William Sanders）称为帕金森病，并于 1875 年由沙尔科的代表德西雷-马格卢瓦尔·布尔内维尔（Désiré-Magloire Bourneville）采用。这篇文章纪念了利奥波德·奥登斯坦和让-马丁·沙尔科开创性工作发表 150 周年。
