Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
Int J Mol Sci. 2020 May 14;21(10):3483. doi: 10.3390/ijms21103483.
Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune diseases. In this paper, we take an overview of the present state of knowledge with regards to complex mechanisms of methotrexate action and its applications as immunosuppressive drug or chemotherapeutic agent in oncological combination therapy. In addition, the issue of the potential benefits of methotrexate in the development of neurological disorders in Alzheimer's disease or myasthenia gravis will be discussed.
甲氨蝶呤是叶酸的结构类似物，是治疗多种癌症或严重和耐药形式的自身免疫性疾病最有效和广泛使用的药物之一。在本文中，我们概述了关于甲氨蝶呤作用的复杂机制及其作为免疫抑制剂或化学治疗剂在肿瘤联合治疗中的应用的现有知识状态。此外，还将讨论甲氨蝶呤在阿尔茨海默病或重症肌无力的神经退行性疾病发展中的潜在益处的问题。
