Links T P, Zwarts M J, Oosterhuis H J
Department of Neurology, University Hospital, Groningen, The Netherlands.
J Neurol Neurosurg Psychiatry. 1988 Sep;51(9):1142-5. doi: 10.1136/jnnp.51.9.1142.
A double blind cross-over study of eight patients with familial hypokalaemic periodic paralysis was made to assess the influence of acetazolamide on muscle strength. All patients had a reduced interictal muscle fibre conduction velocity. Five patients had no attacks at the time of the study. One patient withdrew from the study because of an adverse reaction. The muscle strength of 11 muscle groups was measured with a hand-held dynamometer. The sum of force improved significantly in the seven patients (mean increase: 17%, p less than 0.05; 95% confidence interval: 7.2-26.8%). Endurance tests showed an improvement in the performance of 30 full kneebends. Surface EMG measurement showed no change in the muscle fibre conduction velocity or power spectra during treatment. The integrated EMG showed a (non significant) mean increase of 21%.
对8例家族性低钾性周期性麻痹患者进行了双盲交叉研究，以评估乙酰唑胺对肌肉力量的影响。所有患者发作间期肌纤维传导速度均降低。5例患者在研究时未发作。1例患者因不良反应退出研究。用手持测力计测量11个肌肉群的肌肉力量。7例患者的力量总和显著改善（平均增加：17%，p<0.05；95%置信区间：7.2-26.8%）。耐力测试显示30次全膝关节屈伸的表现有所改善。表面肌电图测量显示治疗期间肌纤维传导速度或功率谱无变化。积分肌电图显示平均增加21%（无统计学意义）。
