Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Department of Neuro-Oncology, Netherlands Cancer Institute‒Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.
Neuro Oncol. 2019 May 6;21(5):571-584. doi: 10.1093/neuonc/noz012.
Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein we critically review available literature on spinal fluid and plasma circulating tumor cells (CTCs) and cell-free tumor (ctDNA) for diagnosis and monitoring of leptomeningeal and parenchymal brain metastases. We discuss technical issues and propose several potential applications of liquid biopsies in different clinical settings (ie, for initial diagnosis, for assessment during treatment, and for guidance of treatment decisions). Last, ongoing clinical studies on CNS metastases that include liquid biopsies are summarized, and recommendations for future clinical studies are provided.
液体活检采集和分析体液中的肿瘤成分，人们越来越感兴趣的是将液体活检作为原发性和继发性脑肿瘤治疗中肿瘤组织的替代物进行研究。本文批判性地回顾了有关脑脊液和血浆循环肿瘤细胞（CTC）和游离肿瘤（ctDNA）在诊断和监测脑膜和脑实质脑转移中的应用的现有文献。我们讨论了技术问题，并提出了液体活检在不同临床环境中的几种潜在应用（即用于初始诊断、用于治疗期间评估以及用于指导治疗决策）。最后，总结了包含液体活检的 CNS 转移的正在进行的临床研究，并提供了未来临床研究的建议。
