用于精准医学的液体活检样本的分子谱分析
Molecular Profiling of Liquid Biopsy Samples for Precision Medicine.
作者信息
Campos Camila D M, Jackson Joshua M, Witek Małgorzata A, Soper Steven A
出版信息
Cancer J. 2018 Mar/Apr;24(2):93-103. doi: 10.1097/PPO.0000000000000311.
Abstract
In the context of oncology, liquid biopsies consist of harvesting cancer biomarkers, such as circulating tumor cells, tumor-derived cell-free DNA, and extracellular vesicles, from bodily fluids. These biomarkers provide a source of clinically actionable molecular information that can enable precision medicine. Herein, we review technologies for the molecular profiling of liquid biopsy markers with special emphasis on the analysis of low abundant markers from mixed populations.
摘要
在肿瘤学领域，液体活检是指从体液中获取癌症生物标志物，如循环肿瘤细胞、肿瘤来源的游离DNA和细胞外囊泡。这些生物标志物提供了具有临床可操作性的分子信息来源，可实现精准医疗。在此，我们综述了液体活检标志物分子分析技术，特别强调了对混合群体中低丰度标志物的分析。
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