Li Z Y, Wu J L, Li J J, Pei L J
Institute of Population Research, Peking University, Beijing 100871, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2019 Jan 10;40(1):33-40. doi: 10.3760/cma.j.issn.0254-6450.2019.01.008.
To understand the influence of chronic diseases on the risk of impaired activities of daily living (ADL) of the elderly. Baseline data of 10 501 elderly individuals recruited by the Chinese Longitudinal Healthy Longevity Survey in 2002 were used, and follow up for this population was conducted until 2014. Cox Proportional Hazard Model was used to estimate the hazards ratios () for the associations between five kinds of chronic diseases, the number of chronic diseases and the risk of ADL impairment in different age groups of the elderly. Hypertension increased the risk of ADL impairment in the elderly of all age groups, which increased the ADL impaired risk by 43 (=1.43, 95: 1.14-1.79) in group aged 65-74 years, 21 (=1.21, 95: 1.02-1.43) in group aged 75-89 years and 20 (=1.20, 95: 1.02-1.43) in group aged 90-105 years, respectively. Diabetes and cerebrovascular disease increased the ADL impaired risk by 102(=2.02, 95: 1.29-3.17), and 79 (=1.79, 95: 1.24-2.58) in group aged 65-74 years, respectively. 'Suffering from one chronic disease' increased the ADL impaired risk by 13 (=1.13, 95: 1.02-1.25), and suffering from two or more chronic diseases increased the ADL impaired risk by 25 (=1.25, 95: 1.13-1.40) in all the age groups. Suffering from two or more chronic diseases increased the ADL impaired risk by 50 (=1.50, 95: 1.21-1.87) in group aged 65-74 years and 17 (=1.17, 95: 1.01-1.38) in groups aged 75-89 years. Hypertension was one of the most important risk factors for the impaired ADL in the elderly population in all age groups. Hypertension, diabetes, cerebrovascular disease or comorbidity increased the risk of impaired ADL in group aged 65-74 years.
为了解慢性病对老年人日常生活活动(ADL)受损风险的影响。使用了2002年中国老年健康长寿纵向调查招募的10501名老年人的基线数据,并对该人群进行随访直至2014年。采用Cox比例风险模型估计5种慢性病、慢性病数量与不同年龄组老年人ADL受损风险之间关联的风险比(HR)。高血压增加了各年龄组老年人ADL受损的风险,在65 - 74岁组中使ADL受损风险增加43%(HR = 1.43,95%CI:1.14 - 1.79),在75 - 89岁组中增加21%(HR = 1.21,95%CI:1.02 - 1.43),在90 - 105岁组中增加20%(HR = 1.20,95%CI:1.02 - 1.43)。糖尿病和脑血管疾病在65 - 74岁组中分别使ADL受损风险增加102%(HR = 2.02,95%CI:1.29 - 3.17)和79%(HR = 1.79,95%CI:1.24 - 2.58)。“患有一种慢性病”在所有年龄组中使ADL受损风险增加13%(HR = 1.13,95%CI:1.02 - 1.25),患两种或更多种慢性病使ADL受损风险增加25%(HR = 1.25,95%CI:1.13 - 1.40)。患两种或更多种慢性病在65 - 74岁组中使ADL受损风险增加50%(HR = 1.50,95%CI:1.21 - 1.87),在75 - 89岁组中增加17%(HR = 1.17,95%CI:1.01 - 1.38)。高血压是所有年龄组老年人群ADL受损的最重要危险因素之一。高血压、糖尿病、脑血管疾病或合并症增加了65 - 74岁组ADL受损的风险。