Novotny Michal, Klimova Blanka, Valis Martin
Biomedical Research Centrum, University Hospital Hradec Králové, Hradec Králové, Czechia.
Department of Neurology, University Hospital Hradec Kralove, Hradec Králové, Czechia.
Front Neurol. 2019 Jan 8;9:1142. doi: 10.3389/fneur.2018.01142. eCollection 2018.
The purpose of this review study is to reveal a potential threat of one type of such widely used and freely distributed drugs, which are proton pump inhibitors that might be the cause of the onset of both dementia and depression. The authors performed a literature review of available studies on the research topic describing the adverse effect of proton pum inhibitors (PPIs) (omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole, pantoprazole, dexrabeprazole, ilaprazole). For a long time, PPIs were considered to be completely safe drug substances for both short and long-term use. In recent years, there have been a few contradictory studis of absolute safety, especially in patients, who have long been using PPIs. At this time when depression and dementia are rising in the population, this is a very worrying fact that needs to be highlighted, and which needs to be carefully studied and evaluated, ideally trying to prevent it. The findings of most research studies described in this review indicate that there is a direct association between the onset of dementia and depression on one side and the long-term use of PPIs on the other.
本综述研究的目的是揭示一类广泛使用且免费分发的药物——质子泵抑制剂可能存在的潜在威胁，这类药物可能是导致痴呆和抑郁症发作的原因。作者对有关质子泵抑制剂（PPIs）（奥美拉唑、埃索美拉唑、兰索拉唑、右兰索拉唑、雷贝拉唑、泮托拉唑、右雷贝拉唑、艾普拉唑）不良反应的现有研究进行了文献综述。长期以来，PPIs被认为无论短期还是长期使用都是完全安全的药物。近年来，出现了一些关于其绝对安全性的相互矛盾的研究，尤其是在长期使用PPIs的患者中。在抑郁症和痴呆症在人群中发病率不断上升的这个时期，这是一个非常令人担忧的事实，需要予以强调，并且需要仔细研究和评估，理想情况下要设法预防它。本综述中描述的大多数研究结果表明，一方面痴呆和抑郁症的发作与另一方面长期使用PPIs之间存在直接关联。
