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不完全川崎病患者产CTX-M-8超广谱β-内酰胺酶的菌尿症

Bacteriuria With CTX-M-8 Extended-Spectrum β-Lactamase-Producing in a Patient With Incomplete Kawasaki Disease.

作者信息

Kamijo Kaori, Abe Yoshifusa, Kagami Takehi, Ugajin Kazuhisa, Mikawa Takeshi, Fukuchi Kunihiko, Tatsuno Masaru, Itabashi Kazuo

机构信息

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.

Department of Pediatrics, Ebara Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tokyo, Japan.

出版信息

Glob Pediatr Health. 2019 Jan 9;6:2333794X18821944. doi: 10.1177/2333794X18821944. eCollection 2019.

Abstract

We report the case of a 2-month-old infant with incomplete Kawasaki disease that presented as an apparent urinary tract infection. The patient's fever persisted despite antibiotic treatment. Intravenous immunoglobulin and aspirin therapy cured both the incomplete Kawasaki disease and bacterial pyuria. Renal sonography, voiding cystourethrography, and renal parenchyma radionuclide scanning did not detect any abnormalities. Temporary dilation of the coronary artery was noted. In a urine specimen obtained through transurethral catheterization, the growth of 10 colony-forming units/mL of extended-spectrum β-lactamase-producing was detected. Polymerase chain reaction analysis revealed that the enzyme genotype was CTX-M-8, which is a rare type in Japan. In conclusion, attention should be paid to a misleading initial presentation of fever and pyuria, which might be interpreted as urinary tract infection in patients with Kawasaki disease. Furthermore, pediatricians should consider incomplete Kawasaki disease when patients present with fever and pyuria, which are consistent with urinary tract infection, but do not respond to antibiotic treatment.

摘要

我们报告了一例2个月大患有不完全川崎病的婴儿病例,该病例最初表现为疑似尿路感染。尽管使用了抗生素治疗,患儿的发热仍持续存在。静脉注射免疫球蛋白和阿司匹林治疗治愈了不完全川崎病和细菌性脓尿。肾脏超声、排尿性膀胱尿道造影和肾实质放射性核素扫描均未发现任何异常。发现冠状动脉有暂时性扩张。在通过经尿道导管插入术获取的尿液标本中,检测到每毫升尿液中有10个菌落形成单位的产超广谱β-内酰胺酶菌生长。聚合酶链反应分析显示,酶基因型为CTX-M-8,这在日本是一种罕见类型。总之,应注意发热和脓尿的误导性初始表现,这在川崎病患者中可能被解释为尿路感染。此外,当患儿出现与尿路感染相符的发热和脓尿,但对抗生素治疗无反应时,儿科医生应考虑不完全川崎病。

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