Landspitalinn University Hospital, University of Iceland, Reykjavik, Iceland.
University of Iceland, Reykjavik, Iceland.
Rheumatol Int. 2019 Apr;39(4):669-677. doi: 10.1007/s00296-019-04243-6. Epub 2019 Jan 22.
To investigate the association between osteoarthritis (OA) and microvascular pathology, we examined the relationship between retinal microvascular caliber and osteoarthritis of the hand and knee in an elderly population. The AGES-Reykjavik is a population-based, multidisciplinary longitudinal cohort study of aging. Retinal vessel caliber, hand osteoarthritis and total knee joint replacements due to OA were examined in 4757 individuals (mean age 76 ± 5 years; 57% female). Incident knee joint replacements during 5-year follow-up (n = 2961, mean age 75 ± 5 years; 58% female) were also assessed. Logistic regression analysis, adjusting for age, sex, and body mass index, showed an association between narrow arteriolar caliber and hand OA, as well as knee replacement. After adjustment for other covariates, including statin therapy, this association was significant for both hand OA in men and women [OR 1.10(1.03-1.17), p < 0.01] (per unit standard deviation decrease in CRAE) and TKR prevalence [OR 1.15 (1.01-1.32), p = 0.04], especially for men [OR 1.22 (1.00-1.51) p = 0.04] and also for incident TKRs in men [OR 1.50 (1.07-2.10), p = 0.04]. Narrow venular caliber was associated with hand OA in women [OR 1.10 (1.01-1.21), p = 0.03]. Retinal arterial narrowing in hand and knee OA is present in males as well as females. Venular narrowing in hand OA in women was an unexpected finding and is in contrast with the venular widening usually observed in cardiovascular diseases.
为了研究骨关节炎（OA）与微血管病变之间的关系，我们在老年人群中研究了视网膜微血管口径与手部和膝关节 OA 之间的关系。AGES-Reykjavik 是一项基于人群的、多学科的老龄化纵向队列研究。在 4757 名个体（平均年龄 76±5 岁；57%为女性）中检查了视网膜血管口径、手部 OA 和全膝关节置换术（由于 OA）。还评估了 5 年随访期间（n=2961，平均年龄 75±5 岁；58%为女性）的新发膝关节置换术。在调整年龄、性别和体重指数后，发现小动脉口径狭窄与手部 OA 以及膝关节置换术有关。在调整其他协变量（包括他汀类药物治疗）后，男性和女性手部 OA 以及 TKR 患病率的这种关联具有统计学意义[比值比（OR）1.10（1.03-1.17），p<0.01]（每单位 CRAE 标准偏差降低）和 TKR 患病率[OR 1.15（1.01-1.32），p=0.04]，尤其是男性[OR 1.22（1.00-1.51），p=0.04]，男性新发 TKR 也如此[OR 1.50（1.07-2.10），p=0.04]。女性手部 OA 与小静脉口径变窄有关[OR 1.10（1.01-1.21），p=0.03]。手部和膝关节 OA 中的视网膜动脉狭窄存在于男性和女性中。女性手部 OA 中静脉变窄是一个意外发现，与心血管疾病中通常观察到的静脉变宽形成对比。
