• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

PharmGKB summary: Ondansetron and tropisetron pathways, pharmacokinetics and pharmacodynamics.

作者信息

Huddart Rachel, Altman Russ B, Klein Teri E

机构信息

Departments of Biomedical Data Sciences.

Biomedical Engineering.

出版信息

Pharmacogenet Genomics. 2019 Jun;29(4):91-97. doi: 10.1097/FPC.0000000000000369.

DOI:10.1097/FPC.0000000000000369
PMID:30672837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6476683/
Abstract
摘要

相似文献

1
PharmGKB summary: Ondansetron and tropisetron pathways, pharmacokinetics and pharmacodynamics.药物基因组学知识库总结：昂丹司琼和托烷司琼的作用途径、药代动力学和药效学。
Pharmacogenet Genomics. 2019 Jun;29(4):91-97. doi: 10.1097/FPC.0000000000000369.
2
The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron.多态性细胞色素P-4502D6参与5-羟色胺拮抗剂托烷司琼和昂丹司琼的代谢。
Drug Metab Dispos. 1994 Mar-Apr;22(2):269-74.
3
Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of dolasetron. Comparison with other indole-containing 5-HT3 antagonists.参与多潘立酮体外代谢的细胞色素P450酶的特性。与其他含吲哚的5-HT3拮抗剂的比较。
Drug Metab Dispos. 1996 May;24(5):602-9.
4
Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes.根据细胞色素P-450 2D6基因型使用5-羟色胺3型受体拮抗剂进行个体化止吐治疗。
J Clin Oncol. 2002 Jun 15;20(12):2805-11. doi: 10.1200/JCO.2002.09.064.
5
Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children.广泛代谢于主要细胞色素 P450 的药物的基于生理的药代动力学（PBPK）模型在儿童中的预测性能。
Clin Pharmacol Ther. 2018 Jul;104(1):188-200. doi: 10.1002/cpt.905. Epub 2017 Nov 20.
6
Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting.细胞色素P450 2D6代谢与5-羟色胺3型受体拮抗剂用于术后恶心和呕吐
Med Sci Monit. 2005 Oct;11(10):RA322-8. Epub 2005 Sep 26.
7
5-HT3-receptor antagonists and the cytochrome P450 system: clinical implications.5-羟色胺3受体拮抗剂与细胞色素P450系统：临床意义
Cancer J. 2002 Sep-Oct;8(5):405-14. doi: 10.1097/00130404-200209000-00012.
8
Ondansetron and granisetron binding orientation in the 5-HT(3) receptor determined by unnatural amino acid mutagenesis.通过非天然氨基酸诱变确定昂丹司琼和格拉司琼在5-羟色胺(3)受体中的结合方向。
ACS Chem Biol. 2012 Oct 19;7(10):1738-45. doi: 10.1021/cb300246j. Epub 2012 Aug 15.
9
Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.α7选择性激动剂对非洲爪蟾卵母细胞中表达的烟碱样受体和5-羟色胺5HT3受体的活性。
Bioorg Med Chem Lett. 2004 Apr 19;14(8):1849-53. doi: 10.1016/j.bmcl.2003.09.104.
10
Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron.临床药物遗传学实施联盟（CPIC）指南：CYP2D6 基因型与昂丹司琼和托烷司琼的应用。
Clin Pharmacol Ther. 2017 Aug;102(2):213-218. doi: 10.1002/cpt.598. Epub 2017 Apr 6.

引用本文的文献

1
Bayesian Population Pharmacokinetic Modeling of Ondansetron for Neonatal Opioid Withdrawal Syndrome.用于新生儿阿片类药物戒断综合征的昂丹司琼的贝叶斯群体药代动力学建模
Clin Transl Sci. 2025 Feb;18(2):e70147. doi: 10.1111/cts.70147.
2
The role of 5-HT modulation in opioid withdrawal and neonatal opioid withdrawal syndrome: mechanisms and potential serotonergic targets.5-羟色胺调节在阿片类药物戒断及新生儿阿片类药物戒断综合征中的作用：机制及潜在的5-羟色胺能靶点
Expert Opin Investig Drugs. 2025 Jan-Feb;34(1-2):49-59. doi: 10.1080/13543784.2025.2462615. Epub 2025 Feb 8.
3
CYP2D6 genotype and associated 5-HT receptor antagonist outcomes: A systematic review and meta-analysis.CYP2D6基因分型与5-羟色胺受体拮抗剂相关结局：一项系统评价与荟萃分析
Clin Transl Sci. 2025 Feb;18(2):e70108. doi: 10.1111/cts.70108.
4
Effect of Prophylactic Tropisetron on Post-Operative Nausea and Vomiting in Patients Undergoing General Anesthesia: Systematic Review and Meta-Analysis with Trial Sequential Analysis.预防性托烷司琼对全身麻醉患者术后恶心呕吐的影响：系统评价与Meta分析及试验序贯分析
J Pers Med. 2024 Jul 27;14(8):797. doi: 10.3390/jpm14080797.
5
A Physiologically Based Pharmacokinetic Model to Predict Systemic Ondansetron Concentration in Liver Cirrhosis Patients.一种基于生理的药代动力学模型，用于预测肝硬化患者体内昂丹司琼的全身浓度。
Pharmaceuticals (Basel). 2023 Dec 6;16(12):1693. doi: 10.3390/ph16121693.
6
Application of Advanced Technologies-Nanotechnology, Genomics Technology, and 3D Printing Technology-In Precision Anesthesia: A Comprehensive Narrative Review.先进技术（纳米技术、基因组学技术和3D打印技术）在精准麻醉中的应用：一篇全面的叙述性综述
Pharmaceutics. 2023 Sep 6;15(9):2289. doi: 10.3390/pharmaceutics15092289.
7
Genetic Susceptibility Toward Nausea and Vomiting in Surgical Patients.外科患者恶心呕吐的遗传易感性
Front Genet. 2022 Jan 31;12:816908. doi: 10.3389/fgene.2021.816908. eCollection 2021.
8
Perioperative pain management in COVID-19 patients: Considerations and recommendations by the Saudi Anesthesia Society (SAS) and Saudi Society of Pain Medicine (SSPM).COVID-19患者围手术期疼痛管理：沙特麻醉学会（SAS）和沙特疼痛医学学会（SSPM）的考量与建议
Saudi J Anaesth. 2021 Jan-Mar;15(1):59-69. doi: 10.4103/sja.SJA_765_20. Epub 2021 Jan 5.
9
Perspectives from the Society for Pediatric Research: pharmacogenetics for pediatricians.儿科研究学会观点：儿科医生的药物遗传学。
Pediatr Res. 2022 Feb;91(3):529-538. doi: 10.1038/s41390-021-01499-2. Epub 2021 Apr 6.

本文引用的文献

1
Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron.临床药物遗传学实施联盟（CPIC）指南：CYP2D6 基因型与昂丹司琼和托烷司琼的应用。
Clin Pharmacol Ther. 2017 Aug;102(2):213-218. doi: 10.1002/cpt.598. Epub 2017 Apr 6.
2
Comparative Pharmacology and Guide to the Use of the Serotonin 5-HT Receptor Antagonists for Postoperative Nausea and Vomiting.《5-HT 受体拮抗剂用于术后恶心呕吐的比较药理学和使用指南》。
Drugs. 2016 Dec;76(18):1719-1735. doi: 10.1007/s40265-016-0663-3.
3
Local-anesthetic like inhibition of the cardiac sodium channel Nav1.5 α-subunit by 5-HT3 receptor antagonists.5-HT3受体拮抗剂对心脏钠通道Nav1.5α亚基的局部麻醉样抑制作用。
Eur J Pharmacol. 2016 Oct 15;789:119-126. doi: 10.1016/j.ejphar.2016.07.020. Epub 2016 Jul 9.
4
Ondansetron Exposure Changes in a Pregnant Woman.一名孕妇体内昂丹司琼的暴露量变化
Pharmacotherapy. 2016 Sep;36(9):e139-41. doi: 10.1002/phar.1796. Epub 2016 Jul 25.
5
Pharmacokinetics and bioavailability study of two ondansetron oral soluble film formulations in fasting healthy male Chinese volunteers.两种昂丹司琼口腔速溶膜制剂在空腹健康中国男性志愿者中的药代动力学和生物利用度研究。
Drug Des Devel Ther. 2015 Aug 12;9:4621-9. doi: 10.2147/DDDT.S86415. eCollection 2015.
6
A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant.5-羟色胺3型受体拮抗剂可增强选择性5-羟色胺再摄取抑制剂类抗抑郁药的行为、神经化学及电生理作用。
Pharmacol Biochem Behav. 2015 Apr;131:136-42. doi: 10.1016/j.pbb.2015.02.011. Epub 2015 Feb 16.
7
Ondansetron pharmacokinetics in pregnant women and neonates: towards a new treatment for neonatal abstinence syndrome.昂丹司琼在孕妇和新生儿中的药代动力学：寻求新生儿戒断综合征的新治疗方法。
Clin Pharmacol Ther. 2015 Feb;97(2):167-76. doi: 10.1002/cpt.5. Epub 2014 Dec 4.
8
Bioequivalence of ondansetron oral soluble film 8 mg (ZUPLENZ) and ondansetron orally disintegrating tablets 8 mg (ZOFRAN) in healthy adults.8毫克昂丹司琼口腔可溶性薄膜（祖普伦）与8毫克昂丹司琼口腔崩解片（佐芬）在健康成年人中的生物等效性。
Am J Ther. 2015 Mar-Apr;22(2):90-7. doi: 10.1097/MJT.0000000000000174.
9
The effect of ondansetron on the efficacy of postoperative tramadol: a systematic review and meta-analysis of a drug interaction.昂丹司琼对曲马多术后疗效的影响：药物相互作用的系统评价和荟萃分析。
Anaesthesia. 2015 Feb;70(2):209-18. doi: 10.1111/anae.12948. Epub 2014 Dec 10.
10
Effects of prophylactic ramosetron and ondansetron on corrected QT interval during general anesthesia.全麻期间预防性雷莫司琼和昂丹司琼对校正 QT 间期的影响。
J Clin Anesth. 2014 Nov;26(7):511-6. doi: 10.1016/j.jclinane.2014.02.011. Epub 2014 Oct 18.