Fontela Paula Caitano, Abdala Franciele Aline Norberto Branquinho, Forgiarini Soraia Genebra Ibrahim, Forgiarini Luiz Alberto
Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.
Centro Universitário Metodista IPA - Porto Alegre (RS), Brasil.
Rev Bras Ter Intensiva. 2018 Oct-Dec;30(4):496-507. doi: 10.5935/0103-507X.20180071.
To assess the long-term, health-related quality of life of intensive care unit survivors by systematic review.
The search for, and selection and analysis of, observational studies that assessed the health-related quality of life of intensive care unit survivors in the electronic databases LILACS and MEDLINE® (accessed through PubMed) was performed using the indexed MESH terms "quality of life [MeSH Terms]" AND "critically illness [MeSH Terms]". Studies on adult patients without specific prior diseases published in English in the last 5 years were included in this systematic review. The citations were independently selected by three reviewers. Data were standardly and independently retrieved by two reviewers, and the quality of the studies was assessed using the Newcastle-Ottawa scale.
In total, 19 observational cohort and 2 case-control studies of 57,712 critically ill patients were included. The follow-up time of the studies ranged from 6 months to 6 years, and most studies had a 6-month or 1-year follow up. The health-related quality of life was assessed using two generic tools, the EuroQol and the Short Form Health Survey. The overall quality of the studies was low.
Long-term, health-related quality of life is compromised among intensive care unit survivors compared with the corresponding general population. However, it is not significantly affected by the occurrence of sepsis, delirium, and acute kidney injury during intensive care unit admission when compared with that of critically ill patient control groups. High-quality studies are necessary to quantify the health-related quality of life among intensive care unit survivors.
通过系统评价评估重症监护病房幸存者与健康相关的长期生活质量。
使用索引医学主题词“生活质量[医学主题词]”和“危重病[医学主题词]”，在电子数据库LILACS和MEDLINE®（通过PubMed访问）中检索、筛选和分析评估重症监护病房幸存者与健康相关生活质量的观察性研究。本系统评价纳入过去5年以英文发表的、无特定既往疾病的成年患者研究。由三位审阅者独立筛选文献。由两位审阅者标准且独立地提取数据，并使用纽卡斯尔-渥太华量表评估研究质量。
总共纳入了19项观察性队列研究和2项病例对照研究，涉及57712例危重病患者。研究的随访时间从6个月到6年不等，大多数研究的随访时间为6个月或1年。使用两种通用工具，即欧洲五维度健康量表和简短健康调查问卷，评估与健康相关的生活质量。研究的总体质量较低。
与相应的普通人群相比，重症监护病房幸存者与健康相关的长期生活质量受到损害。然而，与危重病患者对照组相比，在重症监护病房住院期间发生脓毒症、谵妄和急性肾损伤并不会显著影响其生活质量。需要高质量的研究来量化重症监护病房幸存者与健康相关的生活质量。
