Tacey Alexander, Parker Lewan, Yeap Bu B, Joseph John, Lim Ee M, Garnham Andrew, Hare David L, Brennan-Speranza Tara, Levinger Itamar
Institute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia.
Department of Medicine-Western Health, Australian Institute for Musculoskeletal Science (AIMSS), Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.
Endocr Connect. 2019 Feb;8(2):111-119. doi: 10.1530/EC-18-0473.
The aim of this study was to investigate the effect of a single dose of prednisolone on (A) high-intensity interval cycling performance and (B) post-exercise metabolic, hormonal and haematological responses. Nine young men participated in this double-blind, randomised, cross-over study. The participants completed exercise sessions (4 × 4 min cycling bouts at 90-95% of peak heart rate), 12 h after ingesting prednisolone (20 mg) or placebo. Work load was adjusted to maintain the same relative heart rate between the sessions. Exercise performance was measured as total work performed. Blood samples were taken at rest, immediately post exercise and up to 3 h post exercise. Prednisolone ingestion decreased total work performed by 5% (P < 0.05). Baseline blood glucose was elevated following prednisolone compared to placebo (P < 0.001). Three hours post exercise, blood glucose in the prednisolone trial was reduced to a level equivalent to the baseline concentration in the placebo trial (P > 0.05). Prednisolone suppressed the increase in blood lactate immediately post exercise (P < 0.05). Total white blood cell count was elevated at all time-points with prednisolone (P < 0.01). Androgens and sex hormone-binding globulin were elevated immediately after exercise, irrespective of prednisolone or placebo. In contrast, prednisolone significantly reduced the ratio of testosterone/luteinizing hormone (P < 0.01). Acute prednisolone treatment impairs high-intensity interval cycling performance and alters metabolic and haematological parameters in healthy young men. Exercise may be an effective tool to minimise the effect of prednisolone on blood glucose levels.
本研究的目的是调查单剂量泼尼松龙对（A）高强度间歇骑行表现以及（B）运动后代谢、激素和血液学反应的影响。九名年轻男性参与了这项双盲、随机、交叉研究。参与者在摄入泼尼松龙（20毫克）或安慰剂12小时后完成运动课程（4次4分钟的骑行回合，心率达到峰值心率的90 - 95%）。调整工作量以在各回合之间维持相同的相对心率。运动表现通过所完成的总工作量来衡量。在静息状态、运动后即刻以及运动后长达3小时采集血样。摄入泼尼松龙使所完成的总工作量降低了5%（P < 0.05）。与安慰剂相比，泼尼松龙使基线血糖升高（P < 0.001）。运动后3小时，泼尼松龙试验中的血糖降至与安慰剂试验中的基线浓度相当的水平（P > 0.05）。泼尼松龙抑制了运动后即刻血乳酸的增加（P < 0.05）。泼尼松龙在所有时间点均使白细胞总数升高（P < 0.01）。无论泼尼松龙或安慰剂如何，运动后即刻雄激素和性激素结合球蛋白均升高。相比之下，泼尼松龙显著降低了睾酮/促黄体生成素的比值（P < 0.01）。急性泼尼松龙治疗会损害健康年轻男性的高强度间歇骑行表现，并改变代谢和血液学参数。运动可能是将泼尼松龙对血糖水平的影响降至最低的有效手段。
