Arlettaz A, Collomp K, Portier H, Lecoq A-M, Pelle A, de Ceaurriz J
Atosep Laboratory, Faculty of Sports Sciences, University of Orleans, Vendôme street BP 6237, 45062 Orléans, France.
Int J Sports Med. 2006 Sep;27(9):673-9. doi: 10.1055/s-2005-872826.
To study the effects of a therapeutical dose of corticosteroid alone or associated with beta-2 agonist on performance and substrate response during intense submaximal exercise, seven healthy moderately trained male volunteers participated in the double-blind randomized cross-over study. An intense endurance exercise test to exhaustion was performed after ingestion of placebo (Pla), 20 mg prednisolone (Pred), and 20 mg prednisolone plus 4 mg salbutamol (Pred-Sal). Blood samples were collected at rest, after 5, 10 min of exercise, at exhaustion, and after 5 (r5), 10 (r10), and 20 (r20) min of passive recovery for ACTH, growth hormone, insulin, blood glucose, and lactate measurements. There were no significant differences in exercise time to exhaustion between the three treatments (Pla: 21.5 +/- 2.9; Pred: 22.0 +/- 2.5; Pred-Sal: 24.2 +/- 2.8 min). ACTH was significantly lowered after Pred and Pred-Sal vs. Pla from the start of exercise to the end of the experiment (p < 0.05). Pred and Pred-Sal increased resting and recovery (r10 and r20) significantly but not exercise blood glucose values. There were no significant differences in growth hormone concentrations between the three treatments whereas insulin was significantly higher at rest, during exercise, and at r20 after Pred-Sal administration vs. Pred and Pla (p < 0.05). Pred and Pred-Sal showed no significant effect on blood lactate compared with Pla treatment. These preliminary results do not support the hypothesis that acute oral therapeutic corticosteroid intake alone or associated with beta-2 mimetic improves performance during intense submaximal exercise, but further studies are necessary with tests of longer duration.
为研究治疗剂量的皮质类固醇单独使用或与β-2激动剂联合使用对次极量强度运动期间运动表现和底物反应的影响，七名健康的中度训练男性志愿者参与了这项双盲随机交叉研究。在摄入安慰剂（Pla）、20毫克泼尼松龙（Pred）和20毫克泼尼松龙加4毫克沙丁胺醇（Pred-Sal）后，进行了一项至疲劳的高强度耐力运动测试。在静息状态、运动5分钟、10分钟后、疲劳时以及被动恢复5分钟（r5）、10分钟（r10）和20分钟（r20）后采集血样，用于检测促肾上腺皮质激素（ACTH）、生长激素、胰岛素、血糖和乳酸。三种治疗方案之间至疲劳的运动时间无显著差异（Pla：21.5±2.9；Pred：22.0±2.5；Pred-Sal：24.2±2.8分钟）。从运动开始到实验结束，Pred和Pred-Sal组的ACTH相较于Pla组显著降低（p<0.05）。Pred和Pred-Sal显著增加了静息和恢复（r10和r20）时的血糖值，但未增加运动时的血糖值。三种治疗方案之间生长激素浓度无显著差异，而Pred-Sal给药后，静息、运动期间以及r20时的胰岛素水平相较于Pred和Pla组显著升高（p<0.05）。与Pla治疗相比，Pred和Pred-Sal对血乳酸无显著影响。这些初步结果不支持急性口服治疗剂量的皮质类固醇单独使用或与β-2激动剂联合使用可改善次极量强度运动期间运动表现的假设，但需要进行更长时间测试的进一步研究。
