Sao San Htun Hospital, Taunggyi, Shan States, Burma.
Southeast Asian J Trop Med Public Health. 1988 Jun;19(2):253-8.
Fifty-two patients with falciparum malaria during pregnancy were studied in Taunggyi, Shan States, Burma, during the period of April 1985 through December 1986. Severely ill cases were all treated with quinine, but uncomplicated cases were randomised to receive either quinine or amodiaquine. Fifty-one age-matched non-pregnant female patients were also randomised to receive either quinine or amodiaquine. All clinical and laboratory parameters were comparable between pregnant and non-pregnant group of patients. Falciparum malaria was most frequent among primigravidae, and occurred most frequently in the second trimester for all parities. There were no differences in parasite density, fever clearance and parasite clearance between groups with different parity or gestational period. Quinine and amodiaquine treatment were equally effective. The outcome of pregnancy with and without anti-malarial prophylaxis is discussed.
1985年4月至1986年12月期间，在缅甸掸邦东枝对52例孕期恶性疟患者进行了研究。重症病例均用奎宁治疗，但轻症病例被随机分为接受奎宁或氨酚喹治疗。51例年龄匹配的非孕女性患者也被随机分为接受奎宁或氨酚喹治疗。孕妇组和非孕妇组患者的所有临床和实验室参数具有可比性。初产妇中恶性疟最为常见，各胎次中均以妊娠中期最为高发。不同胎次或妊娠期的组间在寄生虫密度、热退清和寄生虫清除方面无差异。奎宁和氨酚喹治疗效果相同。本文讨论了有无疟疾预防措施情况下的妊娠结局。
