Department of preventive and biomedical science, Faculty of dentistry, University of Science and Technology, Sana'a, Yemen.
Department of periodontology, Faculty of dentistry, Thamar University, Thamar, Yemen.
Clin Oral Investig. 2019 Oct;23(10):3833-3842. doi: 10.1007/s00784-019-02813-3. Epub 2019 Jan 23.
To compare the efficacy of N-acetyl cysteine (NAC) mouthwash with chlorhexidine (CHX) in prevention and treatment of experimental gingivitis MATERIALS AND METHODS: Sixty subjects were assigned randomly and blindly into one of three equal groups: NAC, CHX, or placebo group. The study was conducted in two stages: preventive and treatment substudies. Professional prophylaxis was performed ahead of starting the preventive substudy. Then, the subjects were instructed to stop oral hygiene practices and begin rinsing twice/day with 15 ml of the assigned mouthwash (1.25% NAC, 0.2% CHX, or inert base). Plaque index (PI), gingival index (GI), and papillary bleeding index (PBI) were measured at baseline, 7, 14, and 21 days. The treatment substudy started on day 21 in which the subjects in the placebo group (now with established experimental gingivitis) were assigned to NAC (n = 10) or CHX (n = 10); the abovementioned indices were measured at 28 and 35 days. Efficacy of these interventions was compared.
All groups accumulated plaque and developed some degree of gingivitis: full-blown in the placebo group and remarkably mild in the CHX group. NAC had slight preventive properties at days 14 and 21. In the treatment substudy, CHX was associated with remarkable reduction in plaque and gingivitis while NAC resulted in insignificant reductions.
1.25% NAC is marginally effective in prevention and treatment of experimental gingivitis.
When compared with the placebo, NAC showed promising preventive and treatment effects of gingivitis that deserve further development and studies.
ISRCTN31352091.
比较 N-乙酰半胱氨酸（NAC）漱口水与洗必泰（CHX）在预防和治疗实验性牙龈炎中的疗效。
将 60 名受试者随机分为三组：NAC 组、CHX 组和安慰剂组。研究分为两个阶段：预防研究和治疗研究。在开始预防研究之前进行专业预防。然后，指示受试者停止口腔卫生措施，每天用 15ml 指定漱口水（1.25%NAC、0.2%CHX 或惰性基底）漱口两次。在基线、第 7、14 和 21 天测量菌斑指数（PI）、牙龈指数（GI）和乳头出血指数（PBI）。在第 21 天开始治疗研究，安慰剂组（现已有实验性牙龈炎）的受试者被分配到 NAC（n=10）或 CHX（n=10）组；在第 28 和 35 天测量上述指标。比较这些干预措施的疗效。
所有组都有菌斑积累和一定程度的牙龈炎：安慰剂组为完全发作，CHX 组为明显轻度。NAC 在第 14 和 21 天具有轻微的预防作用。在治疗研究中，CHX 与菌斑和牙龈炎的显著减少有关，而 NAC 则导致无显著减少。
1.25%NAC 在预防和治疗实验性牙龈炎方面有一定效果。
与安慰剂相比，NAC 对牙龈炎显示出有希望的预防和治疗效果，值得进一步开发和研究。
ISRCTN31352091。
