Anderson G B, Bowden J, Morrison E C, Caffesse R G
University of Texas-Houston, Department of Stomatology, Houston 77030-3402, USA.
Am J Orthod Dentofacial Orthop. 1997 Jun;111(6):606-12. doi: 10.1016/s0889-5406(97)70312-3.
This study compared the short-term clinical effect of 0.12% chlorhexidine gluconate and placebo mouthrinses in 30 adolescents (ages 11 to 15) undergoing orthodontic treatment. Subjects were randomized into experimental (CHX) and control (C) groups. Baseline values were recorded 10 days after prophylaxis and included Plaque index (PI), Gingival index (GI), Rentention Index (RI), Discoloration index (DI), and probing depths (PD). Both groups (CHX and C) received soft toothbrushes with instructions to brush twice daily, as well as the CHX and placebo mouthrinses, respectively, with oral and written instructions for rinsing twice daily with 15 ml for 30 seconds. Reevaluations were performed 1, 2, and 3 months after baseline, except for the DI and PD, which were only assessed at 3 months. The Student's t test and the paired t test were used to analyze the data at the P < 0.05 level of significance. No differences between groups were seen at baseline for any of the parameters. At 30 days, there was a significant difference for the RI between CHX (0.15 +/- 0.16; mean +/- SD) and C (0.05 +/- 0.06) at the mesial buccal, and for CHX (0.07 +/- 0.10) and C (0.02 +/- 0.05) at the midbuccal. The 60-day evaluation showed similar results. At 90 days, lower PI were observed in the CHX group at the distal buccal (0.38 +/- 0.19), midbuccal (0.22 +/- 0.17), and mesial buccal (0.47 +/- 0.22) sites as compared with the C group (0.97 +/- 0.38, 0.83 +/- 0.40, and 0.95 +/- 0.43, respectively). A similar trend was noted with the GI, as the lower values were related to the CHX group. The changes of the PI and GI, at 30, 60, and 90 days, as analyzed by the paired t test, were statistically significant in the case of the experimental group, as the changes in the means were a reflection of significantly lower scores observed in the experimental group. After 3 months, the DI showed higher scores in the experimental group as compared with the control, but they were not statistically significant. Deeper PD were detected in the C group at 90 days, and they were statistically significant, except for the midlingual site. The RI did not show significant differences at 90 days, but higher values were recorded in the CHX group. The data indicate that the use of the CHX, in addition to regular oral hygiene habits, was effective in reducing plaque and gingivitis in adolescents undergoing orthodontic treatment.
本研究比较了0.12%葡萄糖酸氯己定和安慰剂漱口水对30名接受正畸治疗的青少年（11至15岁）的短期临床效果。受试者被随机分为实验组（CHX）和对照组（C）。在预防性治疗10天后记录基线值，包括菌斑指数（PI）、牙龈指数（GI）、滞留指数（RI）、变色指数（DI）和探诊深度（PD）。两组（CHX组和C组）均收到软牙刷，并被指导每天刷牙两次，同时分别收到CHX漱口水和安慰剂漱口水，并有口头和书面指导，每天用15毫升漱口水漱口两次，每次30秒。在基线后的1、2和3个月进行重新评估，但DI和PD仅在3个月时评估。使用学生t检验和配对t检验在P<0.05的显著性水平下分析数据。在基线时，任何参数在两组之间均未观察到差异。在30天时，CHX组（0.15±0.16；平均值±标准差）和C组（0.05±0.06）在近中颊侧的RI存在显著差异，CHX组（0.07±0.10）和C组（0.02±0.05）在颊中部也存在显著差异。60天评估显示了类似结果。在90天时，与C组（分别为0.97±0.38、0.83±0.40和0.95±0.43）相比，CHX组在远中颊侧（0.38±0.19）、颊中部（0.22±0.17）和近中颊侧（0.47±0.22）部位的PI较低。GI也有类似趋势，较低值与CHX组相关。通过配对t检验分析，在30、60和90天时，实验组的PI和GI变化具有统计学意义，因为平均值的变化反映了实验组观察到的得分显著较低。3个月后，实验组的DI得分高于对照组，但无统计学意义。在90天时，C组检测到更深的PD，除舌中部部位外，均具有统计学意义。90天时RI未显示显著差异，但CHX组记录到更高的值。数据表明，除了常规口腔卫生习惯外，使用CHX对接受正畸治疗的青少年减少菌斑和牙龈炎有效。
