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碱提取多糖诱导肠道富集对荷瘤小鼠外周血蛋白质组学的调控作用

Regulatory Effects of Alkali-Extracted Polysaccharide Induced Intestinal Enrichment on Peripheral Blood Proteomics in Tumor-Bearing Mice.

作者信息

Fan Yuting, Yang Chenqi, Zhao Yiran, Han Xiao, Ji Hongfei, Ren Zhuohao, Ding Wenjie, Ji Haiyu

机构信息

School of Life Sciences, Yantai University, Yantai 264005, China.

College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China.

出版信息

Microorganisms. 2025 Jul 26;13(8):1750. doi: 10.3390/microorganisms13081750.

DOI:10.3390/microorganisms13081750
PMID:40871255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12388226/
Abstract

polysaccharides have demonstrated multiple biological activities including immune regulation, antitumor, and antioxidant properties. The rapid development and integrated application of multi-omics can facilitate the unraveling of the complex network of immune system regulation. In this study, alkali-extracted polysaccharide (CPAP) were prepared, and their effects on gut microbiota compositions, metabolic pathways, and protein expressions in peripheral blood and solid tumors in mice were further evaluated. The 16S rDNA sequencing results showed that CPAP could effectively promote the enrichment of intestinal in tumor-bearing mice. In addition, it could be inferred from peripheral blood and solid tumor proteomics results that CPAP might activate T cell-mediated antitumor immune functions by regulating purine metabolism and alleviate tumor-caused inflammation by promoting neutrophil degranulation, finally inducing apoptosis in tumor cells by increasing oxidative stress. These results will provide a theoretical foundation and data support for the further development of CPAP as dietary adjuvants targeting immune deficiency-related diseases.

摘要

多糖已显示出多种生物学活性，包括免疫调节、抗肿瘤和抗氧化特性。多组学的快速发展和综合应用有助于揭示免疫系统调节的复杂网络。在本研究中，制备了碱提取多糖（CPAP），并进一步评估了它们对小鼠肠道微生物群组成、代谢途径以及外周血和实体瘤中蛋白质表达的影响。16S rDNA测序结果表明，CPAP可有效促进荷瘤小鼠肠道的富集。此外，从外周血和实体瘤蛋白质组学结果可以推断，CPAP可能通过调节嘌呤代谢激活T细胞介导的抗肿瘤免疫功能，并通过促进中性粒细胞脱颗粒减轻肿瘤引起的炎症，最终通过增加氧化应激诱导肿瘤细胞凋亡。这些结果将为CPAP作为针对免疫缺陷相关疾病的膳食佐剂的进一步开发提供理论基础和数据支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/def0bf2486d0/microorganisms-13-01750-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/d183cfe2370e/microorganisms-13-01750-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/30d5cdf14d1f/microorganisms-13-01750-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/cebb79bdebca/microorganisms-13-01750-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/1229e107f6e2/microorganisms-13-01750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/b69f3bf5d1cc/microorganisms-13-01750-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/71a09317386b/microorganisms-13-01750-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/a13186470bb4/microorganisms-13-01750-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/5d072a9f420e/microorganisms-13-01750-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/52d62f41c230/microorganisms-13-01750-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/def0bf2486d0/microorganisms-13-01750-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/d183cfe2370e/microorganisms-13-01750-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/30d5cdf14d1f/microorganisms-13-01750-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/cebb79bdebca/microorganisms-13-01750-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/1229e107f6e2/microorganisms-13-01750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/b69f3bf5d1cc/microorganisms-13-01750-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/71a09317386b/microorganisms-13-01750-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/a13186470bb4/microorganisms-13-01750-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/5d072a9f420e/microorganisms-13-01750-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/52d62f41c230/microorganisms-13-01750-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be2/12388226/def0bf2486d0/microorganisms-13-01750-g010.jpg

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本文引用的文献

[1]
Observer Variation in the Diagnosis of Testicular Sex Cord-Stromal Tumors by a Genitourinary Pathology Society and International Society of Urological Pathology Panel: Paving the Way for a New Classification.

Mod Pathol. 2025-6-3

[2]
-Mediated Regulation of the Microbial-Immune Axis: A Review of Key Mechanisms, Influencing Factors, and Application Prospects.

Foods. 2025-5-16

[3]
Alterations in ether phospholipids metabolism activate the conserved UPR-Xbp1- PDIA3/ERp60 signaling to maintain intestinal homeostasis.

iScience. 2025-2-4

[4]
Structural characteristics and anti-tumor activity of alkali-extracted acidic polysaccharide extracted from Panax ginseng.

Int J Biol Macromol. 2025-5

[5]
Cholesterol metabolism in tumor immunity: Mechanisms and therapeutic opportunities for cancer.

Biochem Pharmacol. 2025-4

[6]
Inflammation and tumor immune escape in response to DNA damage.

Semin Cancer Biol. 2025-5

[7]
Hyodeoxycholic acid inhibits colorectal cancer proliferation through the FXR/EREG/EGFR axis.

Front Cell Dev Biol. 2025-1-6

[8]
Immunoregulatory Effects of Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice.

Foods. 2024-12-17

[9]
Structural characteristics and intestinal flora metabolism mediated immunoregulatory effects of Lactarius deliciosus polysaccharide.

Int J Biol Macromol. 2024-10

[10]
Modulating butyric acid-producing bacterial community abundance and structure in the intestine of immunocompromised mice with neutral polysaccharides extracted from Codonopsis pilosula.

Int J Biol Macromol. 2024-10

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