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Decreased expression of ZO-1 is associated with tumor metastases in liver cancer.紧密连接蛋白1（ZO-1）表达降低与肝癌的肿瘤转移相关。
Oncol Lett. 2019 Feb;17(2):1859-1864. doi: 10.3892/ol.2018.9765. Epub 2018 Nov 27.
2
RBM38 is involved in TGF-β-induced epithelial-to-mesenchymal transition by stabilising zonula occludens-1 mRNA in breast cancer.RBM38通过稳定乳腺癌中紧密连接蛋白1的mRNA，参与转化生长因子-β诱导的上皮-间质转化。
Br J Cancer. 2017 Aug 22;117(5):675-684. doi: 10.1038/bjc.2017.204. Epub 2017 Jul 6.
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MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2.microRNA-493-5p 通过靶向 VAMP2 促进肝癌细胞凋亡，抑制增殖和侵袭。
Int J Mol Med. 2018 Mar;41(3):1740-1748. doi: 10.3892/ijmm.2018.3358. Epub 2018 Jan 2.
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A novel all-trans retinoic acid derivative 4-amino‑2‑trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP.一种新型全反式维甲酸衍生物4-氨基-2-三氟甲基苯基维甲酸酯通过上调p53和ASPP1以及下调iASPP诱导G0/G1期细胞周期阻滞和凋亡，从而抑制人肝癌HepG2细胞的增殖。
Oncol Rep. 2016 Jul;36(1):333-41. doi: 10.3892/or.2016.4795. Epub 2016 May 9.
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MicroRNA-103 regulates the progression in endometrial carcinoma through ZO-1.MicroRNA-103 通过 ZO-1 调控子宫内膜癌的进展。
Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419872621. doi: 10.1177/2058738419872621.
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Loss of tight junction plaque molecules in breast cancer tissues is associated with a poor prognosis in patients with breast cancer.乳腺癌组织中紧密连接斑块分子的缺失与乳腺癌患者的不良预后相关。
Eur J Cancer. 2004 Dec;40(18):2717-25. doi: 10.1016/j.ejca.2004.08.008.
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Long-term exposure to ethanol downregulates tight junction proteins through the protein kinase Cα signaling pathway in human cerebral microvascular endothelial cells.长期暴露于乙醇通过蛋白激酶Cα信号通路下调人脑血管内皮细胞中的紧密连接蛋白。
Exp Ther Med. 2017 Nov;14(5):4789-4796. doi: 10.3892/etm.2017.5180. Epub 2017 Sep 21.
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The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression.长链非编码RNA GAS5通过下调IGF-1R表达，增强吉非替尼对具有野生型EGFR的原发性EGFR酪氨酸激酶抑制剂耐药肺腺癌细胞的诱导细胞死亡作用。
J Hematol Oncol. 2015 Apr 29;8:43. doi: 10.1186/s13045-015-0140-6.
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Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1.天冬酰胺内肽酶通过下调紧密连接蛋白 ZO-1 诱导血管内皮通透性和肿瘤转移。
Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2267-2275. doi: 10.1016/j.bbadis.2019.05.003. Epub 2019 May 13.
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CMTM5 inhibits renal cancer cell growth through inducing cell-cycle arrest and apoptosis.CMTM5通过诱导细胞周期停滞和凋亡来抑制肾癌细胞生长。
Oncol Lett. 2017 Aug;14(2):1536-1542. doi: 10.3892/ol.2017.6350. Epub 2017 Jun 8.
引用本文的文献
1
Clinical applications of circulating tumor cells in metastasis and therapy.循环肿瘤细胞在转移和治疗中的临床应用
J Hematol Oncol. 2025 Aug 22;18(1):80. doi: 10.1186/s13045-025-01733-y.
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Extracellular vesicles: the "Trojan Horse" within breast cancer host microenvironments.细胞外囊泡：乳腺癌宿主微环境中的“特洛伊木马”。
Mol Cancer. 2025 Jun 23;24(1):183. doi: 10.1186/s12943-025-02358-y.
3
Expression of Lumican and Osteopontin in Perivascular Areas of the Glioblastoma Peritumoral Niche and Its Value for Prognosis.纤连蛋白和骨桥蛋白在胶质母细胞瘤瘤周微环境血管周围区域的表达及其预后价值。
Int J Mol Sci. 2024 Dec 29;26(1):192. doi: 10.3390/ijms26010192.
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Sonopermeation With Size-sorted Microbubbles Synergistically Increases Survival and Enhances Tumor Apoptosis With L-DOX by Increasing Vascular Permeability and Perfusion in Neuroblastoma Xenografts.使用大小分选微泡的超声透入通过增加神经母细胞瘤异种移植瘤的血管通透性和灌注，协同提高存活率并增强L-DOX诱导的肿瘤细胞凋亡。
Ultrasound Med Biol. 2025 Feb;51(2):348-357. doi: 10.1016/j.ultrasmedbio.2024.10.014. Epub 2024 Nov 23.
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N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation.N-乙酰葡糖胺基转移酶V通过促进紧密连接蛋白1的泛素化和降解来驱动结直肠癌转移。
Cancer Cell Int. 2024 Nov 7;24(1):366. doi: 10.1186/s12935-024-03551-7.
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overexpression inhibits colorectal cancer cell migration through the regulation of epithelial‑mesenchymal transition.过表达通过调节上皮-间充质转化抑制结直肠癌细胞迁移。
Mol Med Rep. 2024 Nov;30(5). doi: 10.3892/mmr.2024.13325. Epub 2024 Sep 20.
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Preeclampsia in the Context of COVID-19: Mechanisms, Pathophysiology, and Clinical Outcomes.子痫前期与 COVID-19：机制、病理生理学和临床结局。
Am J Reprod Immunol. 2024 Aug;92(2):e13915. doi: 10.1111/aji.13915.
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Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells.膜相关支架紧密连接 (TJ) 蛋白在 B16-F10 小鼠黑色素瘤细胞致瘤特性中的功能分析。
Int J Mol Sci. 2024 Jan 9;25(2):833. doi: 10.3390/ijms25020833.
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CSNK1G2-AS1 promotes metastasis, colony formation and serves as a biomarker in testicular germ cell tumor cells.CSNK1G2反义链1促进睾丸生殖细胞肿瘤细胞的转移、集落形成并作为一种生物标志物。
J Cancer. 2023 Sep 4;14(15):2771-2783. doi: 10.7150/jca.85640. eCollection 2023.
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Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cells.用于永生化和新鲜肿瘤来源的乳腺癌细胞三维培养的重组丝网络的开发与表征
Bioeng Transl Med. 2023 May 11;8(5):e10537. doi: 10.1002/btm2.10537. eCollection 2023 Sep.
本文引用的文献
1
Impact of antiviral therapy on post-hepatectomy outcome for hepatitis B-related hepatocellular carcinoma.抗病毒治疗对乙型肝炎相关肝细胞癌肝切除术后结局的影响。
World J Gastroenterol. 2014 May 28;20(20):6006-12. doi: 10.3748/wjg.v20.i20.6006.
2
[Epidemiology, natural history, and risk factors of hepatocellular carcinoma].[肝细胞癌的流行病学、自然史及危险因素]
Rev Prat. 2013 Feb;63(2):216-7, 220-2.
3
Clinicopathologic analysis of combined hepatocellular-cholangiocarcinoma according to the latest WHO classification.根据最新的世界卫生组织分类，对肝细胞癌-胆管细胞癌联合癌进行临床病理分析。
Am J Surg Pathol. 2013 Apr;37(4):496-505. doi: 10.1097/PAS.0b013e31827332b0.
4
International trends in liver cancer incidence rates.全球肝癌发病率趋势。
Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2362-8. doi: 10.1158/1055-9965.EPI-11-0643. Epub 2011 Sep 15.
5
[Targeted therapies in digestive oncology].[消化系统肿瘤的靶向治疗]
Rev Med Suisse. 2011 May 25;7(296):1131-2, 1134-6.
6
EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies.EZH2 蛋白：肝穿刺活检中检测肝细胞癌的一种有前途的免疫标志物。
Gut. 2011 Jul;60(7):967-76. doi: 10.1136/gut.2010.231993. Epub 2011 Feb 17.
7
Global cancer statistics.全球癌症统计数据。
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4.
8
Hepatocellular carcinoma: review of current treatment with a focus on targeted molecular therapies.肝细胞癌：当前治疗方法的综述，重点关注靶向分子治疗。
Therap Adv Gastroenterol. 2010 Jan;3(1):55-66. doi: 10.1177/1756283X09346669.
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Reliability and reproducibility of the edmondson grading of hepatocellular carcinoma using paired core biopsy and surgical resection specimens.应用配对的核心穿刺活检和手术切除标本评估肝细胞癌的 edmondson 分级的可靠性和可重复性。
Arch Pathol Lab Med. 2010 Dec;134(12):1818-22. doi: 10.5858/2009-0551-OAR1.1.
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The liver tissue bank and clinical database in China.中国的肝脏组织库和临床数据库。
Front Med China. 2010 Dec;4(4):443-7. doi: 10.1007/s11684-010-0190-7. Epub 2010 Nov 19.
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